Disruption of amyloid aggregates by artificial ferritins

被引：4

作者：

Balejcikova, L. ^{[1
]}

Petrenko, V. I. ^{[2
,3
]}

Bat'kova, M. ^{[4
]}

Siposova, K. ^{[4
]}

Garamus, V. M. ^{[5
]}

Bulavin, L. A. ^{[3
]}

Avdeev, M. V. ^{[2
]}

Almasy, L. ^{[6
,7
]}

Kopcansky, P. ^{[4
]}

机构：

[1] Slovak Acad Sci, Inst Hydrol, Dubravska Cesta 9, Bratislava 84104, Slovakia

[2] Joint Inst Nucl Res, Joliot Curie St 6, Dubna 141980, Moscow Region, Russia

[3] Taras Shevchenko Natl Univ Kyiv, Volodymyrska St 64, UA-01033 Kiev, Ukraine

[4] Slovak Acad Sci, Inst Expt Phys, Watsonova 47, Kosice 04001, Slovakia

[5] Helmholtz Zentrum Geesthacht Ctr Mat & Coastal Re, Max Planck St 1, D-21502 Geesthacht, Germany

[6] Hungarian Acad Sci, Wigner Res Ctr Phys, Inst Solid State Phys & Opt, POB 49, H-1525 Budapest, Hungary

[7] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Peoples R China

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2019年 / 473卷

关键词：

Amyloid aggregates; Magnetoferritin; Ferritin; Interactions between amyloid and magnetic materials; Anti-amyloid effect; Disruption of amyloid; ABNORMAL PROTEIN AGGREGATION; SMALL-ANGLE SCATTERING; MAGNETOFERRITIN STRUCTURE; HEN LYSOZYME; NANOPARTICLES; FIBRILLATION; INHIBITORS; MECHANISM; KINETICS; FIBRILS;

D O I：

10.1016/j.jmmm.2018.10.055

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Presence of protein amyloid aggregates is associated with many neurodegenerative disorders, such as Alzheimer's disease etc. The effect of magnetoferritin and reconstructed ferritin on the structure of lysozyme amyloid aggregates was studied using small-angle X-ray scattering, atomic force microscopy and thioflavin T fluorescence measurements. It has been shown that both magnetoferritin and reconstructed ferritin molecules affect the size, structure and amount of the amyloid fibrils. We assume that the anti-amyloid effect of magnetoferritin and reconstructed ferritin is due to the presence of iron in solutions but is not associated with the magnetic character of the iron oxide phases, i.e. magnetite/maghemite for magnetoferritin and ferrihydrite for ferritin.

引用

页码：215 / 220

页数：6

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