Activity-based probes as molecular tools for biomarker discovery

被引：8
|
作者：
Carvalho, L. A. R. [1 ]
Ruivo, E. F. P. [1 ]
Lucas, S. D. [1 ]
Moreira, R. [1 ]
机构：
[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal
来源：
MEDCHEMCOMM | 2015年 / 6卷 / 04期
关键词：
PROTEASES RECENT ADVANCES; ACTIVITY-BASED PROTEOMICS; ENZYME-ACTIVITY PROFILES; FUNCTIONAL PROTEOMICS; FLUOROGENIC PROBES; TUMOR-GROWTH; PROTEIN; CYSTEINE; SERINE; VALIDATION;
D O I：
10.1039/c4md00417e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biomarker discovery and validation techniques have been extensively developed together with the "omics" era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.
引用
收藏
页码：536 / 546
页数：11
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