Activity-based probes as molecular tools for biomarker discovery

被引：8

作者：

Carvalho, L. A. R. ^{[1
]}

Ruivo, E. F. P. ^{[1
]}

Lucas, S. D. ^{[1
]}

Moreira, R. ^{[1
]}

机构：

[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

来源：

MEDCHEMCOMM | 2015年 / 6卷 / 04期

关键词：

PROTEASES RECENT ADVANCES; ACTIVITY-BASED PROTEOMICS; ENZYME-ACTIVITY PROFILES; FUNCTIONAL PROTEOMICS; FLUOROGENIC PROBES; TUMOR-GROWTH; PROTEIN; CYSTEINE; SERINE; VALIDATION;

D O I：

10.1039/c4md00417e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarker discovery and validation techniques have been extensively developed together with the "omics" era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.

引用

页码：536 / 546

页数：11

共 50 条

[21] The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery
Carvalho, Luis A. R.
Bernardes, Goncalo J. L.
CHEMMEDCHEM, 2022, 17 (14)
[22] Detection of ubiquitin-proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development
Kramer, Holger B.
Nicholson, Benjamin
Kessler, Benedikt M.
Altun, Mikael
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2012, 1823 (11): : 2029 - 2037
[23] A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes
Wright, Aaron T.
Song, Joongyu D.
Cravatt, Benjamin F.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (30) : 10692 - 10700
[24] Furin-targeting activity-based probes with phosphonate and phosphinate esters as warheads
Ji, Shanping
Verhelst, Steven H. L.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2023, 21 (32) : 6498 - 6502
[25] Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides
Chavas, Thomas E. J.
Fuchter, Matthew J.
DiMaggio, Peter A., Jr.
ACS CHEMICAL BIOLOGY, 2018, 13 (10) : 2897 - 2907
[26] Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases
Ramos-Llorca, Alba
Decraecker, Lisse
Cacheux, Valerie M. Y.
Zeiburlina, Irena
De Bruyn, Michelle
Battut, Louise
Moreno-Cinos, Carlos
Ceradini, Davide
Espinosa, Eric
Dietrich, Gilles
Berg, Maya
De Meester, Ingrid
van der Veken, Pieter
Boeckxstaens, Guy
Lambeir, Anne-Marie
Denadai-Souza, Alexandre
Augustyns, Koen
FRONTIERS IN CHEMISTRY, 2023, 10
[27] Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery
Love, Kerry Routenberg
Pandya, Renuka K.
Spooner, Eric
Ploegh, Hidde L.
ACS CHEMICAL BIOLOGY, 2009, 4 (04) : 275 - 287
[28] Research Advances Through Activity-Based Lipid Hydrolase Profiling
Honeder, Sophie Elisabeth
Tomin, Tamara
Schinagl, Maximilian
Pfleger, Raphael
Hoehlschen, Julia
Darnhofer, Barbara
Schittmayer, Matthias
Birner-Gruenberger, Ruth
ISRAEL JOURNAL OF CHEMISTRY, 2023, 63 (3-4)
[29] Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity
Ourailidou, Maria E.
Lenoci, Alessia
Zwergel, Clemens
Rotili, Dante
Mai, Antonello
Dekker, Frank J.
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (03) : 847 - 856
[30] Phosphinate Esters as Novel Warheads for Quenched Activity-Based Probes Targeting Serine Proteases
Kahler, Jan Pascal
Ji, Shanping
Speelman-Rooms, Femke
Vanhoutte, Roeland
Verhelst, Steven H. L.
ACS CHEMICAL BIOLOGY, 2024, 19 (07) : 1409 - 1415

← 1 2 3 4 5 →