Activity-based probes as molecular tools for biomarker discovery

被引：8
作者：
Carvalho, L. A. R. [1 ]
Ruivo, E. F. P. [1 ]
Lucas, S. D. [1 ]
Moreira, R. [1 ]
机构：
[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal
来源：
MEDCHEMCOMM | 2015年 / 6卷 / 04期
关键词：
PROTEASES RECENT ADVANCES; ACTIVITY-BASED PROTEOMICS; ENZYME-ACTIVITY PROFILES; FUNCTIONAL PROTEOMICS; FLUOROGENIC PROBES; TUMOR-GROWTH; PROTEIN; CYSTEINE; SERINE; VALIDATION;
D O I：
10.1039/c4md00417e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biomarker discovery and validation techniques have been extensively developed together with the "omics" era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.
引用
收藏
页码：536 / 546
页数：11
相关论文
共 78 条
[1]   Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype [J].
Adam, GC ;
Sorensen, EJ ;
Cravatt, BF .
NATURE BIOTECHNOLOGY, 2002, 20 (08) :805-809
[2]   Profiling the specific reactivity of the proteome with non-directed activity-based probes [J].
Adam, GC ;
Cravatt, BF ;
Sorensen, EJ .
CHEMISTRY & BIOLOGY, 2001, 8 (01) :81-95
[3]   Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[4]   Discovering disease-associated enzymes by proteome reactivity profiling [J].
Barglow, KT ;
Cravatt, BF .
CHEMISTRY & BIOLOGY, 2004, 11 (11) :1523-1531
[5]   Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-An update on patient populations with a wide range of cardiovascular risk [J].
Boeger, Rainer H. ;
Maas, Renke ;
Schulze, Friedrich ;
Schwedhelm, Edzard .
PHARMACOLOGICAL RESEARCH, 2009, 60 (06) :481-487
[6]   Mass spectrometry-based proteomics: qualitative identification to activity-based protein profiling [J].
Cardoza, Job D. ;
Parikh, Jignesh R. ;
Ficarro, Scott B. ;
Marto, Jarrod A. .
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2012, 4 (02) :141-162
[7]   A bright approach to the immunoproteasome: Development of LMP2/β1i-specific imaging probes [J].
Carmony, Kimberly Cornish ;
Lee, Do-Min ;
Wu, Ying ;
Lee, Na-Ra ;
Wehenkel, Marie ;
Lee, Jason ;
Lei, Beilei ;
Zhan, Chang-Guo ;
Kim, Kyung-Bo .
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (02) :607-613
[8]   Development of an Activity-Based Probe for Autotaxin [J].
Cavalli, Silvia ;
Houben, Anna J. S. ;
Albers, Harald M. H. G. ;
van Tilburg, Erica W. ;
de Ru, Arnoud ;
Aoki, Junken ;
van Veelen, Peter ;
Moolenaar, Wouter H. ;
Ovaa, Huib .
CHEMBIOCHEM, 2010, 11 (16) :2311-2317
[9]   Developing a strategy for activity-based detection of enzymes in a protein microarray [J].
Chen, GYJ ;
Uttamchandani, M ;
Zhu, Q ;
Wang, G ;
Yao, SQ .
CHEMBIOCHEM, 2003, 4 (04) :336-339
[10]   Fluorogenic Probes with Substitutions at the 2 and 7 Positions of Cephalosporin are Highly BlaC-Specific for Rapid Mycobacterium tuberculosis Detection [J].
Cheng, Yunfeng ;
Xie, Hexin ;
Sule, Preeti ;
Hassounah, Hany ;
Graviss, Edward A. ;
Kong, Ying ;
Cirillo, Jeffrey D. ;
Rao, Jianghong .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (35) :9360-9364
12345678