Activity-based probes as molecular tools for biomarker discovery

被引：8

作者：

Carvalho, L. A. R. ^{[1
]}

Ruivo, E. F. P. ^{[1
]}

Lucas, S. D. ^{[1
]}

Moreira, R. ^{[1
]}

机构：

[1] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

来源：

MEDCHEMCOMM | 2015年 / 6卷 / 04期

关键词：

PROTEASES RECENT ADVANCES; ACTIVITY-BASED PROTEOMICS; ENZYME-ACTIVITY PROFILES; FUNCTIONAL PROTEOMICS; FLUOROGENIC PROBES; TUMOR-GROWTH; PROTEIN; CYSTEINE; SERINE; VALIDATION;

D O I：

10.1039/c4md00417e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarker discovery and validation techniques have been extensively developed together with the "omics" era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.

引用

页码：536 / 546

页数：11

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