Design and Fabrication of Organ-on-Chips: Promises and Challenges

被引:51
|
作者
Tajeddin, Alireza [1 ]
Mustafaoglu, Nur [1 ,2 ]
机构
[1] Sabanci Univ, Fac Engn & Nat Sci, TR-34596 Istanbul, Turkey
[2] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34596 Istanbul, Turkey
关键词
organ-on-chips; microfabrication; microfluidics; 3D organ models; ELECTRICAL-RESISTANCE TEER; A-CHIP; MICROFLUIDIC DEVICES; MICROPHYSIOLOGICAL SYSTEMS; NEURODEGENERATIVE DISEASE; DRUG DISCOVERY; CELL-CULTURE; IN-VITRO; 3D; MODELS;
D O I
10.3390/mi12121443
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The advent of the miniaturization approach has influenced the research trends in almost all disciplines. Bioengineering is one of the fields benefiting from the new possibilities of microfabrication techniques, especially in cell and tissue culture, disease modeling, and drug discovery. The limitations of existing 2D cell culture techniques, the high time and cost requirements, and the considerable failure rates have led to the idea of 3D cell culture environments capable of providing physiologically relevant tissue functions in vitro. Organ-on-chips are microfluidic devices used in this context as a potential alternative to in vivo animal testing to reduce the cost and time required for drug evaluation. This emerging technology contributes significantly to the development of various research areas, including, but not limited to, tissue engineering and drug discovery. However, it also brings many challenges. Further development of the technology requires interdisciplinary studies as some problems are associated with the materials and their manufacturing techniques. Therefore, in this paper, organ-on-chip technologies are presented, focusing on the design and fabrication requirements. Then, state-of-the-art materials and microfabrication techniques are described in detail to show their advantages and also their limitations. A comparison and identification of gaps for current use and further studies are therefore the subject of the final discussion.
引用
收藏
页数:33
相关论文
共 50 条
  • [21] UV-triggered polymerization of polycatecholamines enables the production of organ-on-chips inside a biosafety cabinet
    Khetani, Sultan
    Yong, Kar Wey
    Guan, Kevin
    Singh, Anupriya
    Phani, Arindam
    Kollath, Vinayaraj Ozhukil
    Kim, Seonghwan
    Karan, Kunal
    Sen, Arindom
    Sanati-Nezhad, Amir
    APPLIED MATERIALS TODAY, 2020, 20
  • [22] Ecological design: Promises and challenges
    Saito, Y
    ENVIRONMENTAL ETHICS, 2002, 24 (03) : 243 - 261
  • [23] Wireless NoC as Interconnection Backbone for Multicore Chips: Promises and Challenges
    Deb, Sujay
    Ganguly, Amlan
    Pande, Partha Pratim
    Belzer, Benjamin
    Heo, Deukhyoun
    IEEE JOURNAL ON EMERGING AND SELECTED TOPICS IN CIRCUITS AND SYSTEMS, 2012, 2 (02) : 228 - 239
  • [24] Comparative Analysis of Blood-Derived Endothelial Cells for Designing Next-Generation Personalized Organ-on-Chips
    Mathur, Tanmay
    Tronolone, James J.
    Jain, Abhishek
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 10 (22):
  • [25] Challenges and Promises in the Fabrication of Bit Patterned Media
    Moneck, Matthew T.
    Zhu, Jian-Gang
    PHOTOMASK TECHNOLOGY 2010, 2010, 7823
  • [26] Systems on chips: Design challenges
    Bennour, Imed E.
    Tourki, Racked
    Advances in Physics, Electronics and Signal Processing Applications, 2000, : 209 - 214
  • [27] Deceased organ donation and transplantation in India: Promises and challenges
    Srivastava, Aneesh
    Mani, Anil
    NEUROLOGY INDIA, 2018, 66 (02) : 316 - 322
  • [28] Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy
    Richardson, Lauren S.
    Kammala, Ananth K.
    Costantine, Maged M.
    Fortunato, Stephen J.
    Radnaa, Enkhtuya
    Kim, Sungjin
    Taylor, Robert N.
    Han, Arum
    Menon, Ramkumar
    LAB ON A CHIP, 2022, 22 (23) : 4574 - 4592
  • [29] Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
    Novak, Richard
    Didier, Meredyth
    Calamari, Elizabeth
    Ng, Carlos F.
    Choe, Youngjae
    Clauson, Susan L.
    Nestor, Bret A.
    Puerta, Jefferson
    Fleming, Rachel
    Firoozinezhad, Sasan J.
    Ingber, Donald E.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2018, (140):
  • [30] The optimization paradigm in engineering design: promises and challenges
    Papalambros, PY
    COMPUTER-AIDED DESIGN, 2002, 34 (12) : 939 - 951