Molecular physiology of syndromic obesities in humans

被引:21
作者
Chung, WK
Leibel, RL
机构
[1] Columbia Univ, Coll Med, Div Mol Genet, New York, NY 10032 USA
[2] Columbia Univ, Coll Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
关键词
D O I
10.1016/j.tem.2005.06.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity has become an increasingly prevalent public health problem and represents the complex interaction of genetic, developmental, behavioral and environmental influences. Although rare, the study of syndromic forms of obesity provides insight into underlying molecular and physiological mechanisms by which adiposity is regulated through food intake, energy expenditure and partitioning of stored calories.
引用
收藏
页码:267 / 272
页数:6
相关论文
共 61 条
  • [31] JONES KL, 1996, RECOGNIZABLE PATTERN, P202
  • [32] The oligogenic properties of Bardet-Biedl syndrome
    Katsanis, N
    [J]. HUMAN MOLECULAR GENETICS, 2004, 13 : R65 - R71
  • [33] SYNDROME OF LAURENCE-MOON-BARDET-BIEDL AND ALLIED DISEASES IN SWITZERLAND . CLINICAL, GENETIC AND EPIDEMIOLOGICAL STUDIES
    KLEIN, D
    AMMANN, F
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1969, 9 (03) : 479 - &
  • [34] Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract
    Kojima, M
    Kangawa, K
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (06) : 665 - 668
  • [35] Cohen syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport
    Kolehmainen, J
    Black, GCM
    Saarinen, A
    Chandler, K
    Clayton-Smith, J
    Träskelin, AL
    Perveen, R
    Kivitie-Kallio, S
    Norio, R
    Warburg, M
    Fryns, JP
    de la Chapelle, A
    Lehesjoki, AE
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (06) : 1359 - 1369
  • [36] Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse
    Kulaga, HM
    Leitch, CC
    Eichers, ER
    Badano, JL
    Lesemann, A
    Hoskins, BE
    Lupski, JR
    Beales, PL
    Reed, RR
    Katsanis, N
    [J]. NATURE GENETICS, 2004, 36 (09) : 994 - 998
  • [37] Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain
    Lee, S
    Walker, CL
    Wevrick, R
    [J]. GENE EXPRESSION PATTERNS, 2003, 3 (05) : 599 - 609
  • [38] Mutations in PHF6 are associated with Borjeson-Forssman-Lehmann syndrome
    Lower, KM
    Turner, G
    Kerr, BA
    Mathews, KD
    Shaw, MA
    Gedeon, AK
    Schelley, S
    Hoyme, HE
    White, SM
    Delatycki, MB
    Lampe, AK
    Clayton-Smith, J
    Stewart, H
    van Ravenswaay, CMA
    de Vries, BBA
    Cox, B
    Grompe, M
    Ross, S
    Thomas, P
    Mulley, JC
    Gécz, J
    [J]. NATURE GENETICS, 2002, 32 (04) : 661 - 665
  • [39] Marshall JD, 1997, AM J MED GENET, V73, P150, DOI 10.1002/(SICI)1096-8628(19971212)73:2<150::AID-AJMG9>3.0.CO
  • [40] 2-Y