Molecular physiology of syndromic obesities in humans

被引:21
作者
Chung, WK
Leibel, RL
机构
[1] Columbia Univ, Coll Med, Div Mol Genet, New York, NY 10032 USA
[2] Columbia Univ, Coll Med, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
关键词
D O I
10.1016/j.tem.2005.06.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity has become an increasingly prevalent public health problem and represents the complex interaction of genetic, developmental, behavioral and environmental influences. Although rare, the study of syndromic forms of obesity provides insight into underlying molecular and physiological mechanisms by which adiposity is regulated through food intake, energy expenditure and partitioning of stored calories.
引用
收藏
页码:267 / 272
页数:6
相关论文
共 61 条
  • [1] Allison DB, 1996, INT J OBESITY, V20, P990
  • [2] Alstrom C.H., 1959, ACTA PSYCH NEUROL SC, V129, P1
  • [3] [Anonymous], 1999, ELS OCEAN ENGN BK S
  • [4] Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome
    Ansley, SJ
    Badano, JL
    Blacque, OE
    Hill, J
    Hoskins, BE
    Leitch, CC
    Kim, JC
    Ross, AJ
    Eichers, ER
    Teslovich, TM
    Mah, AK
    Johnsen, RC
    Cavender, JC
    Lewis, RA
    Leroux, MR
    Beales, PL
    Katsanis, N
    [J]. NATURE, 2003, 425 (6958) : 628 - 633
  • [5] Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus
    Badano, JL
    Kim, JC
    Hoskins, BE
    Lewis, RA
    Ansley, SJ
    Cutler, DJ
    Castellan, C
    Beales, PL
    Leroux, MR
    Katsanis, N
    [J]. HUMAN MOLECULAR GENETICS, 2003, 12 (14) : 1651 - 1659
  • [6] Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome
    Beales, PL
    Badano, JL
    Ross, AJ
    Ansley, SJ
    Hoskins, BE
    Kirsten, B
    Mein, CA
    Froguel, P
    Scambler, PJ
    Lewis, RA
    Lupski, JR
    Katsanis, N
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) : 1187 - 1199
  • [7] BELL AJ, 1992, J INTELL DISABIL RES, V36, P359
  • [8] Psychotic illness in people with Prader Willi syndrome due to chromosome 15 maternal uniparental disomy
    Boer, H
    Holland, A
    Whittington, J
    Butler, J
    Webb, T
    Clarke, D
    [J]. LANCET, 2002, 359 (9301) : 135 - 136
  • [9] BORJESON M, 1962, ACTA MED SCAND, V171, P13
  • [10] Body-mass index and mortality in a prospective cohort of US adults
    Calle, EE
    Thun, MJ
    Petrelli, JM
    Rodriguez, C
    Heath, CW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (15) : 1097 - 1105