Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers

被引：9

作者：

Ding, Jun ^{[1
]}

Ding, Zhengang ^{[2
]}

Yuan, Fang ^{[1
]}

Guo, Jianyi ^{[1
]}

Chen, Hao ^{[1
]}

Gao, Wenwei ^{[1
]}

Wang, Ren ^{[1
]}

Gu, Yi ^{[1
]}

Chen, Jiong ^{[1
]}

Guo, Yan ^{[1
]}

Tian, Hengli ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Neurosurg, Shanghai 200233, Peoples R China

[2] Chinese Med Hosp Huangdao Dist Jiaonan, Dept Neurosurg, Jiaonan 266406, Shandong, Peoples R China

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2015年 / 73卷 / 04期

关键词：

traumatic brain injury; biomarkers; proteomics; two-dimensional gel electrophoresis; mass spectrometry; PYRUVATE-KINASE M2; ALPHA-II-SPECTRIN; CEREBROSPINAL-FLUID; SERUM BIOMARKERS; PEDIATRIC TBI; PROTEIN; S100B; RESPONSES; HYPOXIA; MODELS;

D O I：

10.1590/0004-282X20150006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Many studies of protein expression after traumatic brain injury (TBI) have identified biomarkers for diagnosing or determining the prognosis of TBI. In this study, we searched for additional protein markers of TBI using a fluid perfusion impact device to model TBI in S-D rats. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins. After proteomic analysis, we detected 405 and 371 protein spots within a pH range of 3-10 from sham-treated and contused brain cortex, respectively. Eighty protein spots were differentially expressed in the two groups and 20 of these proteins were identified. This study validated the established biomarkers of TBI and identified potential biomarkers that could be examined in future work.

引用

页码：342 / 349

页数：8

共 50 条

[31] Clinical complications after a traumatic brain injury and its relation with brain biomarkers
Oriol Yuguero
Maria Bernal
Joan Farré
Montserrat Martinez-Alonso
Ana Vena
Francisco Purroy
Scientific Reports, 13
[32] In Search of Biomarkers for Late Recovery of Patients with Traumatic Brain Injury: A Multimodal Approach
Schnakers, Caroline
Divine, James
Johnson, Micah
Patterson, David
Jensen, Gary
Rosario, Emily
BRAIN INJURY, 2019, 33 : 208 - 209
[33] Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury
Francesca Polito
Fausto Famà
Rosaria Oteri
Giovanni Raffa
Gianluca Vita
Alfredo Conti
Sacco Daniele
Vincenzo Macaione
Marcello Passalacqua
Salvatore Cardali
Rosa Maria Di Giorgio
Maria Gioffrè
Flavio F. Angileri
Antonino Germanò
M’Hammed Aguennouz
Molecular Biology Reports, 2020, 47 : 2941 - 2949
[34] Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury
Polito, Francesca
Fama, Fausto
Oteri, Rosaria
Raffa, Giovanni
Vita, Gianluca
Conti, Alfredo
Daniele, Sacco
Macaione, Vincenzo
Passalacqua, Marcello
Cardali, Salvatore
Di Giorgio, Rosa Maria
Gioffre, Maria
Angileri, Flavio F.
Germano, Antonino
Aguennouz, M'Hammed
MOLECULAR BIOLOGY REPORTS, 2020, 47 (04) : 2941 - 2949
[35] MicroRNAs as potential biomarkers for the diagnosis of Traumatic Brain Injury: A systematic review and meta-analysis
Zhou, Qian
Yin, Jian
Wang, Yadong
Zhuang, Xinsuo
He, Zhiyang
Chen, Zuobing
Yang, Xiaofeng
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2021, 18 (01): : 128 - 136
[36] Potential Biomarkers of impulsivity in mild traumatic brain injury: A pilot study
Cardoso, Maira Gloria de Freitas
de Barros, Joao Luis Vieira Monteiro
de Queiroz, Rafael Alves Bonfim
Rocha, Natalia Pessoa
Silver, Carlisa
da Silva, Agnes Stephanie
da Silva, Ewelin Wasner Machado
Roque, Isadora Goncalves
Carvalho, Julia de Lima
dos Santos, Laura Ferreira
Cota, Leticia Bitencourt
Lemos, Lucas Miranda
Miranda, Mariana Figueiredo
Miranda, Millena Figueiredo
Vianna, Pedro Parenti
Oliveira, Rafael Arantes
Furlam, Tiago de Oliveira
Soares, Tulio Safar Sarquis
Pedroso, Vinicius Sousa Pietra
Faleiro, Rodrigo Moreira
Vieira, Erica Leandro Marciano
Teixeira, Antonio Lucio
de Souza, Leonardo Cruz
de Miranda, Aline Silva
BEHAVIOURAL BRAIN RESEARCH, 2023, 449
[37] Emodin attenuates brain edema after traumatic brain injury in rats
Zeng, Jian-Ping
Jia, Li-Tao
Jin, Xin
Zheng, Ju-Ping
Zhang, Xin-Wen
Zhan, Ren-Ya
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (11): : 15213 - 15220
[38] Ulinastatin Attenuates Brain Edema After Traumatic Brain Injury in Rats
Cui, Tao
Zhu, Gangyi
CELL BIOCHEMISTRY AND BIOPHYSICS, 2015, 71 (02) : 595 - 600
[39] Ulinastatin Attenuates Brain Edema After Traumatic Brain Injury in Rats
Tao Cui
Gangyi Zhu
Cell Biochemistry and Biophysics, 2015, 71 : 595 - 600
[40] Biomarkers in Silent Traumatic Brain Injury
Antonopoulos, Constantine N.
Kadoglou, Nikolaos P. E.
CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (06) : 680 - 687

← 1 2 3 4 5 →