Opioids in pain medicine

被引：0

作者：

Casely, Emma ^{[1
]}

Laycock, Helen ^{[2
,3
]}

机构：

[1] Great Ormond St Hosp Sick Children, Anaesthesia, London, England

[2] Great Ormond St Hosp Sick Children, Paediat Pain Med & Anaesthet, London, England

[3] Royal Coll Anaesthetists, Fac Pain, Training & Assessment Comm, London, England

来源：

ANAESTHESIA AND INTENSIVE CARE MEDICINE | 2022年 / 23卷 / 07期

关键词：

Analgesics; clinical; drug administration routes; genetic; opioid; pharmacology; polymorphism; receptors; MECHANISMS;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Opioids represent one of the most important classes of analgesic medication and are effective in acute and cancer pain management. Concerns exist regarding their utility in chronic non-cancer pain due to consequences of long-term use and lack of efficacy. Opioids bind to G protein-coupled receptors leading to a variety of physiological effects, including analgesia. Individual drug pharmacokinetics and pharmacodynamics, actions across different physiological systems, side-effect profiles, routes of administration and patient factors that impact on drug efficacy, all need to be considered when choosing the appropriate opioid and preparation for individual patients.

引用

页码：384 / 390

页数：7

共 19 条

[1] Hot topics in opioid pharmacology: mixed and biased opioids
Azzam, Ammar A. H.
McDonald, John
Lambert, David G.
[J]. BRITISH JOURNAL OF ANAESTHESIA, 2019, 122 (06) : E136 - E145
[2] Borsodi A., 2019, IUPHAR BPS GUIDE PHA, V4, DOI [10.2218/gtopdb/F50/2019.4, DOI 10.2218/GTOPDB/F50/2019.4]
[3] A BRIEF-HISTORY OF OPIATES, OPIOID-PEPTIDES, AND OPIOID RECEPTORS
BROWNSTEIN, MJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) : 5391 - 5393
[4] Consensus statement from the BJA Workshop on Cancer and Anaesthesia
Buggy, D. J.
Borgeat, A.
Cata, J.
Doherty, D. G.
Doornebal, C. W.
Forget, P.
Gottumukkala, V.
Gottschalk, A.
Gupta, A.
Gupta, K.
Hales, T. G.
Hemmings, H. C.
Hollmann, M. W.
Kurz, A.
Ma, D.
Parat, M. O.
Sessler, D. I.
Shorten, G.
Singleton, P.
[J]. BRITISH JOURNAL OF ANAESTHESIA, 2015, 114 (01) : 2 - 3
[5] Opioids and the Blood-Brain Barrier: A Dynamic Interaction with Consequences on Drug Disposition in Brain
Chaves, Catarina
Remiao, Fernando
Cisternino, Salvatore
Decleves, Xavier
[J]. CURRENT NEUROPHARMACOLOGY, 2017, 15 (08) : 1156 - 1173
[6] The Effectiveness and Risks of Long-Term Opioid Therapy for Chronic Pain: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop
Chou, Roger
Turner, Judith A.
Devine, Emily B.
Hansen, Ryan N.
Sullivan, Sean D.
Blazina, Ian
Dana, Tracy
Bougatsos, Christina
Deyo, Richard A.
[J]. ANNALS OF INTERNAL MEDICINE, 2015, 162 (04) : 276 - +
[7] Differences between opioids: pharmacological, experimental, clinical and economical perspectives
Drewes, Asbjorn M.
Jensen, Rasmus D.
Nielsen, Lecia M.
Droney, Joanne
Christrup, Lona L.
Arendt-Nielsen, Lars
Riley, Julia
Dahan, Albert
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (01) : 60 - 78
[8] Reframing the Opioid Epidemic as a National Emergency
Gostin, Lawrence O.
Hodge, James G., Jr.
Noe, Sarah A.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (16): : 1539 - 1540
[9] Techniques of opioid administration
Green, Christopher J. G.
Bagchi, Somnath
[J]. ANAESTHESIA AND INTENSIVE CARE MEDICINE, 2019, 20 (08) : 430 - 435
[10] Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression
Imam, Mohammad Zafar
Kuo, Andy
Ghassabian, Sussan
Smith, Maree T.
[J]. NEUROPHARMACOLOGY, 2018, 131 : 238 - 255

← 1 2 →