Nickel-Catalyzed Reductive Amidation of Unactivated Alkyl Bromides

被引：66

作者：

Serrano, Eloisa ^{[1
]}

Martin, Ruben ^{[1
,2
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Ave Paisos Catalans 16, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 37期

关键词：

cross-coupling; nickel; reductive coupling; synthetic methods; CROSS-COUPLING REACTIONS; TERTIARY ALKYL; HALIDES; ISOCYANATES; ALKENES; AMINOCARBONYLATION; CARBOXYLATION; OLEFINS; AMINES; AMIDES;

D O I：

10.1002/anie.201605162

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.

引用

页码：11207 / 11211

页数：5

共 70 条

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