The use of hematopoietic stem cells in autoimmune diseases

被引：11

作者：

Ben Nasr, Moufida ^{[1
,2
]}

Bassi, Roberto ^{[1
,2
]}

Usuelli, Vera ^{[2
]}

Valderrama-Vasquez, Alessandro ^{[2
]}

Tezza, Sara ^{[1
]}

D'Addio, Francesca ^{[1
,2
]}

Fiorina, Paolo ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

[2] IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy

来源：

REGENERATIVE MEDICINE | 2016年 / 11卷 / 04期

关键词：

autoimmune diseases; hematopoietic stem cells; Type; 1; diabetes; BONE-MARROW-TRANSPLANTATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; NONOBESE DIABETIC MICE; TOTAL-BODY IRRADIATION; ZEALAND BLACK MICE; PROGENITOR CELLS; TOLERANCE INDUCTION; RECENT-ONSET; NOD MICE; PULSE CYCLOPHOSPHAMIDE;

D O I：

10.2217/rme-2015-0057

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cyclophasmide). Furthermore, recent trials reported positive results by using HSCs in treatment of systemic sclerosis, multiple sclerosis and rheumatoid arthritis as well. Early data suggested that HSCs possess immunological properties that may be harnessed to alleviate the symptoms of individuals with autoimmune disorders and possibly induce remission of autoimmune diseases. Mechanistically, HSCs may facilitate the generation of regulatory T cells, may inhibit the function of autoreactive T-cell function and may reshape the immune system.

引用

页码：395 / 405

页数：11

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