共 107 条
The use of hematopoietic stem cells in autoimmune diseases
被引:11
作者:

Ben Nasr, Moufida
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA
IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

Bassi, Roberto
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA
IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

Usuelli, Vera
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

Valderrama-Vasquez, Alessandro
论文数: 0 引用数: 0
h-index: 0
机构:
IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

Tezza, Sara
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA

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Fiorina, Paolo
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA
IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA
机构:
[1] Harvard Univ, Sch Med, Nephrol Div, Boston Childrens Hosp, Boston, MA USA
[2] IRCCS Osped San Raffaele, Transplant Med Div, Milan, Italy
关键词:
autoimmune diseases;
hematopoietic stem cells;
Type;
1;
diabetes;
BONE-MARROW-TRANSPLANTATION;
SYSTEMIC-LUPUS-ERYTHEMATOSUS;
NONOBESE DIABETIC MICE;
TOTAL-BODY IRRADIATION;
ZEALAND BLACK MICE;
PROGENITOR CELLS;
TOLERANCE INDUCTION;
RECENT-ONSET;
NOD MICE;
PULSE CYCLOPHOSPHAMIDE;
D O I:
10.2217/rme-2015-0057
中图分类号:
Q813 [细胞工程];
学科分类号:
摘要:
Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cyclophasmide). Furthermore, recent trials reported positive results by using HSCs in treatment of systemic sclerosis, multiple sclerosis and rheumatoid arthritis as well. Early data suggested that HSCs possess immunological properties that may be harnessed to alleviate the symptoms of individuals with autoimmune disorders and possibly induce remission of autoimmune diseases. Mechanistically, HSCs may facilitate the generation of regulatory T cells, may inhibit the function of autoreactive T-cell function and may reshape the immune system.
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页码:395 / 405
页数:11
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Harvard Univ, Sch Med, Boston Childrens Hosp, Div Nephrol, Boston, MA 02115 USA
Univ Milan, Osped San Raffaele, IRCCS, I-20127 Milan, Italy Harvard Univ, Sch Med, Boston Childrens Hosp, Div Nephrol, Boston, MA 02115 USA