Results of medical follow-up program were analyzed with the aim to reveal the health effects of low-dose irradiation exposure in personnel of Chernobyl nuclear power station and to elaborate the complex of medical, prophylactic and social measures for minimizing the negative influence and preservation of professional abilities. Chernobyl station personnel with the doses exceeding the professional limits and clean-up workers of 1986/87 were the objects of special attention. High frequency of stress-related pathology - neurasthenic and psychasthenic reactions, cardio-vascular pathology, such as ischemic heart disease and arterial hypertension, gastro-intestinal erosive and ulcerous changes. Wavy variations were shown in the diseases clinical course with the depressive, atrophic and scleroatrophic changes development tendencies in the gastro-intestinal, bronchopulmonary, haemopoetic and immune systems. Stress reactions were characteristic for the reactor operators and administrative staff. Results of complex clinical evaluation of health effects in the personnel of the IV reactor zone (Shelter) are discussed. The role of the peculiarities of professional activities was the point of interest including the elevated irradiation levels and possible radioactive dust inhalation effects. Investigation also included endocrine function studies and metabolic changes. Prevalence of micro-dot cataracts and vascular eye pathology was detected while typical radiation cataracts were diagnosed rarely. Mechanisms of adaptation reactions during the professional activities in the zone of elevated radiation levels are discussed. Systemic homeostatic reactions were shown to play the major role in the early irradiation effects as well as in the repair of the radiation injuries. Impairment of pro-oxidation balance was shown with the shift to oxidative processes. The up-to-date scientific and medical studies of Chornobyl personnel could be useful in the future efforts determination.