Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma

被引：11

作者：

Teng, Yaoshu ^{[1
,2
]}

Li, Yuandong ^{[2
]}

Lin, Zhihong ^{[3
]}

Gao, Yueqiu ^{[1
,2
]}

Cao, Xiaolin ^{[1
,2
]}

Lou, Xiangyu ^{[1
,2
]}

Lin, Fengchun ^{[4
]}

Li, Yong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hangzhou First Peoples Hosp, Dept Otorhinolaryngol, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Fourth Clin Med Coll, Dept Otorhinolaryngol, Hangzhou 310006, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Otorhinolaryngol, Hangzhou 310008, Zhejiang, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Pathol, Hangzhou 310008, Zhejiang, Peoples R China

来源：

EPIGENOMICS | 2018年 / 10卷 / 12期

关键词：

bioinformatics; biomarker; Human papilloma virus; inverted papilloma; microarray; microRNA; pathogenesis; pathway; sinonasal tumors; target genes; DOWN-REGULATION; MICRORNAS; PLAY; HEAD;

D O I：

10.2217/epi-2018-0071

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). Materials & methods: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods. Results: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence. Conclusion: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP. [GRAPHICS] .

引用

页码：1541 / 1553

页数：14

共 38 条

[31] Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression [J].

Fan, Zhen ;

Chen, Xiaowei ;

Chen, Runsheng .

GENOMICS, 2014, 103 (01) :76-82

[32] Bioinformatics Analysis of Microarray Profiling Identifies That the miR-203-3p Target Ppp2ca Aggravates Seizure Activity in Mice [J].

Zhang, Lifang ;

Li, Yanran ;

Ye, Xuexue ;

Bian, Lin .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2018, 66 (01) :146-154

[33] A Multiscale In Silico Analysis Identifies Plasma Levels of miR-223-3p as an Emerging Biomarker of Cardiac Response to Acute Exercise and Training in Olympic Medallists [J].

Fernandez-Vivero, D. ;

Terrados, N. ;

Pinto-Hernandez, P. ;

Noguero-Lopez, C. ;

Fernandez-Garcia, B. ;

Whitham, M. ;

Iglesias-Gutierrez, E. ;

Fernandez-Sanjurjo, M. .

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2025, 35 (06)

[34] MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab [J].

Mlcochova, Jitka ;

Faltejskova-Vychytilova, Petra ;

Ferracin, Manuela ;

Zagatti, Barbara ;

Radova, Lenka ;

Svoboda, Marek ;

Nemecek, Radim ;

John, Stanislav ;

Kiss, Igor ;

Vyzula, Rostislav ;

Negrini, Massimo ;

Slaby, Ondrej .

ONCOTARGET, 2015, 6 (36) :38695-38704

[35] Evaluation of MiR-1908-3p as a novel serum biomarker for breast cancer and analysis its oncogenic function and target genes [J].

Zhu, Youzhi ;

Wang, Qingshui ;

Xia, Yun ;

Xiong, Xiaoxue ;

Weng, Shuyun ;

Ni, Huizhen ;

Ye, Yan ;

Chen, Ling ;

Lin, Junyu ;

Chen, Yajuan ;

Niu, Haitao ;

Chen, Xiangjin ;

Lin, Yao .

BMC CANCER, 2020, 20 (01)

[36] 3D Cell Culture-Based Global miRNA Expression Analysis Reveals miR-142-5p as a Theranostic Biomarker of Rectal Cancer Following Neoadjuvant Long-Course Treatment [J].

Kunigenas, Linas ;

Stankevicius, Vaidotas ;

Dulskas, Audrius ;

Budginaite, Elzbieta ;

Alzbutas, Gediminas ;

Stratilatovas, Eugenijus ;

Cordes, Nils ;

Suziedelis, Kestutis .

BIOMOLECULES, 2020, 10 (04)

[37] Microarray profiling analysis identifies the mechanism of miR-200b-3p/mRNA-CD36 affecting diabetic cardiomyopathy via peroxisome proliferator activated receptor-γ signaling pathway [J].

Xu, Liqiong ;

Chen, Wei ;

Ma, Min ;

Chen, Anfang ;

Tang, Chengyue ;

Zhang, Chengwei ;

Cai, Lin .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (04) :5193-5206

[38] Integrated analysis of tyrosine-induced MiRNA and mRNA expression profiles in melanocytes reveals the regulatory role of miR-1560-3p in melanin deposition in Xichuan black-bone chickens [J].

Zhang, Zhiyuan ;

Zhang, Pengwei ;

He, Fumin ;

Hou, Yingdong ;

Geng, Xiaowen ;

Xu, Ruilong ;

Li, Ruiting ;

Tian, Yadong ;

Li, Wenting ;

Sun, Guirong ;

Jiang, Ruirui ;

Liu, Xiaojun ;

Han, Ruili ;

Li, Guoxi ;

Kang, Xiangtao ;

Li, Donghua .

BMC GENOMICS, 2025, 26 (01)

← 1 2 3 4 →