Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma

被引：11

作者：

Teng, Yaoshu ^{[1
,2
]}

Li, Yuandong ^{[2
]}

Lin, Zhihong ^{[3
]}

Gao, Yueqiu ^{[1
,2
]}

Cao, Xiaolin ^{[1
,2
]}

Lou, Xiangyu ^{[1
,2
]}

Lin, Fengchun ^{[4
]}

Li, Yong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hangzhou First Peoples Hosp, Dept Otorhinolaryngol, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Fourth Clin Med Coll, Dept Otorhinolaryngol, Hangzhou 310006, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Otorhinolaryngol, Hangzhou 310008, Zhejiang, Peoples R China

[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Pathol, Hangzhou 310008, Zhejiang, Peoples R China

来源：

EPIGENOMICS | 2018年 / 10卷 / 12期

关键词：

bioinformatics; biomarker; Human papilloma virus; inverted papilloma; microarray; microRNA; pathogenesis; pathway; sinonasal tumors; target genes; DOWN-REGULATION; MICRORNAS; PLAY; HEAD;

D O I：

10.2217/epi-2018-0071

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). Materials & methods: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods. Results: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence. Conclusion: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP. [GRAPHICS] .

引用

页码：1541 / 1553

页数：14

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