Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma

被引：10
作者：
Teng, Yaoshu [1 ,2 ]
Li, Yuandong [2 ]
Lin, Zhihong [3 ]
Gao, Yueqiu [1 ,2 ]
Cao, Xiaolin [1 ,2 ]
Lou, Xiangyu [1 ,2 ]
Lin, Fengchun [4 ]
Li, Yong [1 ,2 ]
机构：
[1] Zhejiang Univ, Affiliated Hangzhou First Peoples Hosp, Dept Otorhinolaryngol, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Fourth Clin Med Coll, Dept Otorhinolaryngol, Hangzhou 310006, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Otorhinolaryngol, Hangzhou 310008, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Pathol, Hangzhou 310008, Zhejiang, Peoples R China
来源：
EPIGENOMICS | 2018年 / 10卷 / 12期
关键词：
bioinformatics; biomarker; Human papilloma virus; inverted papilloma; microarray; microRNA; pathogenesis; pathway; sinonasal tumors; target genes; DOWN-REGULATION; MICRORNAS; PLAY; HEAD;
D O I：
10.2217/epi-2018-0071
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). Materials & methods: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods. Results: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence. Conclusion: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP. [GRAPHICS] .
引用
收藏
页码：1541 / 1553
页数：14
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