Photodynamic Therapy with 5-Aminolevulinic Acid Patch for the Treatment of Actinic Keratosis

被引：9

作者：

Kiss, Norbert ^{[1
]}

Farkas, Klara ^{[1
]}

Tosti, Giulio ^{[2
]}

De Gado, Federico ^{[3
]}

Bergler-Czop, Beata ^{[4
]}

Fazia, Gilda ^{[3
]}

Tammaro, Antonella ^{[5
]}

Cantisani, Carmen ^{[3
]}

机构：

[1] Semmelweis Univ, Dept Dermatol Venereol & Dermatooncol, H-1085 Budapest, Hungary

[2] European Inst Oncol, Melanoma & Soft Tissue Sarcoma Div, IRCCS, I-20141 Milan, Italy

[3] Sapienza Univ Rome, Dept Dermatol & Venereol, Policlin Umberto I, I-00161 Rome, Italy

[4] Med Univ Silesia, Dept Dermatol, PL-40055 Katowice, Poland

[5] Sapienza Univ Rome, NESMOS Dermatol Dept, I-00189 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 11期

关键词：

5-aminolevulinic acid patch; photodynamic therapy; PDT; daylight; treatment; actinic keratosis; actinic cheilitis; non-melanoma skin cancer; 1 TREATMENT DELIVERY; AMINOLEVULINIC ACID; BOWENS-DISEASE; GUIDELINES; EFFICACY; FACE;

D O I：

10.3390/jcm11113164

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is an emerging treatment option in the care of actinic keratosis (AK). A self-adhesive 5-ALA patch was recently developed that allows a precise PDT procedure. Here, we review the current literature and report the findings of our case series that observed the outcomes and safety of 5-ALA patch PDT. Ten patients with a total of 40 AKs were treated with a single session of conventional or daylight PDT using 5-ALA patch at the Department of Dermatology and Venereology, Sapienza University of Rome or at the European Institute of Oncology, Milan, Italy. Complete response was observed in three patients, while partial response was seen in seven patients. Overall tolerability was good or excellent, with local adverse events observed in four patients. This is the first case series reported where the 5-ALA patch was applied using daylight PDT, and its efficacy and tolerability in the treatment of AK were demonstrated. In conclusion, the self-adhesive 5-ALA patch is a convenient application of PDT that provides a well-tolerated and effective treatment option with satisfactory cosmetic outcomes.

引用

页数：10

共 24 条

[1] Successful Daylight-PDT using a self-adhesive 5-aminolaevulinic acid patch [J].