Sensitivity enhancement based on application of multi-pass interferometry in phase-sensitive surface plasmon resonance biosensor

被引：54
作者：
Ho, H. P. [1 ]
Yuan, W.
Wong, C. L.
Wu, S. Y.
Suen, Y. K.
Kong, S. K.
Lin, Chinlon
机构：
[1] Chinese Univ Hong Kong, Dept Elect Engn, Ctr Adv Res Photon, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China
来源：
OPTICS COMMUNICATIONS | 2007年 / 275卷 / 02期
关键词：
surface plasmon resonance; Fabry-Perot interferometry; biosensor; phase interrogation;
D O I：
10.1016/j.optcom.2007.03.067
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A novel design of multi-pass surface plasmon resonance (SPR) biosensor with differential phase interrogation based on multi-pass interferometry is presented. This new configuration provides an intrinsic phase amplification effect of over twofold by placing the SPR sensor head in a signal arm of the interferometer so that the interrogating optical beam will traverse the sensor surface infinite number of times. Experimental interferometers based on the Michelson and Fabry-Perot configurations have been employed to experimentally verify this amplification effect when they were compared with Mach-Zehnder configuration, results obtained from salt-water mixtures, antibody-antigen.. and protein-DNA binding reaction confirmed the expected phase measurement enhancement, thus leading to the possibility of direct detection of small sized bio-molecules using SPR. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：491 / 496
页数：6
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