Palladium-Assisted Regioselective C-H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source

被引：185

作者：

Xu, Shuguang ^{[1
]}

Huang, Xiaomei ^{[1
]}

Hong, Xiaohu ^{[1
]}

Xu, Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 17期

关键词：

CATALYZED DIRECT CYANATION; CARBON-HYDROGEN BONDS; NITRILE REARRANGEMENT; CALCIUM HALIDES; ISOCYANIDES; INDOLES; TRANSFORMATION; ACTIVATION; INSERTION; N; N-DIMETHYLFORMAMIDE;

D O I：

10.1021/ol302070t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be Efficiently cyanated through C-H bond activation with high regioselectivity.

引用

页码：4614 / 4617

页数：4

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