A direct and versatile access to α,α-disubstituted 2-pyrrolidinylmethanols by Sml2-mediated reductive coupling

被引：40

作者：

Burchak, Olga N. ^{[1
]}

Philouze, Christian ^{[1
]}

Chavant, Pierre Yves ^{[1
]}

Py, Sandrine ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, Dept Chim Mol SERCO, UMR5250,ICMG FR2607, F-38041 Grenoble 09, France

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 14期

关键词：

D O I：

10.1021/ol800982n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various alpha,alpha-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a Sml(2)-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-alpha,alpha-diphenylprolinol is also easily prepared and resolved.

引用

页码：3021 / 3023

页数：3

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