The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

被引：12

作者：

Paragomi, Pedram ^{[1
]}

Dabo, Bashir ^{[2
,3
]}

Pelucchi, Claudio ^{[4
]}

Bonzi, Rossella ^{[4
]}

Bako, Abdulaziz T. ^{[5
]}

Sanusi, Nabila Muhammad ^{[6
]}

Nguyen, Quan H. ^{[7
]}

Zhang, Zuo-Feng ^{[8
,9
]}

Palli, Domenico ^{[10
]}

Ferraroni, Monica ^{[4
]}

Vu, Khanh Truong ^{[11
]}

Yu, Guo-Pei ^{[12
]}

Turati, Federica ^{[4
]}

Zaridze, David ^{[13
]}

Maximovitch, Dmitry ^{[13
]}

Hu, Jinfu ^{[14
]}

Mu, Lina ^{[15
]}

Boccia, Stefania ^{[16
,17
,18
]}

Pastorino, Roberta ^{[16
,17
,18
]}

Tsugane, Shoichiro ^{[19
,20
]}

Hidaka, Akihisa ^{[19
]}

Kurtz, Robert C. ^{[21
]}

Lagiou, Areti ^{[22
]}

Lagiou, Pagona ^{[23
,24
]}

Camargo, M. Constanza ^{[25
]}

Curado, Maria Paula ^{[26
]}

Lunet, Nuno ^{[27
,28
,29
]}

Vioque, Jesus ^{[30
,31
]}

Boffetta, Paolo ^{[32
,33
]}

Negri, Eva ^{[33
]}

La Vecchia, Carlo ^{[4
]}

Luu, Hung N. ^{[1
,34
]}

机构：

[1] Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA 15232 USA

[2] Univ S Florida, Coll Publ Hlth, Epidemiol & Biostat Concentrat, Tampa, FL 33620 USA

[3] Bayero Univ, Coll Hlth Sci, Dept Med Microbiol & Parasitol, Kano 700006, Nigeria

[4] Univ Milan, Dept Clin Sci & Community Hlth, I-20133 Milan, Italy

[5] Houston Methodist Res Inst, Ctr Hlth Data Sci & Analyt, Houston, TX 77030 USA

[6] Bayero Univ, Coll Hlth Sci, Fac Clin Sci, Kano 700006, Nigeria

[7] Univ Queensland, Sch Biomed Sci, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[8] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA

[9] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[10] ISPRO, Inst Canc Res Prevent & Clin Network, Canc Risk Factors & Life Style Epidemiol Unit, I-50139 Florence, Italy

[11] Tam Anh Gen Hosp, Dept Gastroenterol & Pancreatohepatobiliary, Hanoi 100000, Vietnam

[12] Peking Univ, Med Informat Ctr, Beijing 1008, Peoples R China

[13] NN Blokhin Natl Med Res Ctr Oncol, Dept Clin Epidemiol, Moscow 115478, Russia

[14] Harbin Med Univ, Dept Epidemiol, Harbin 150081, Peoples R China

[15] Univ Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14214 USA

[16] Univ Cattolica Sacro Cuore, Univ Dept Life Sci & Publ Hlth, Sect Hyg, I-00168 Rome, Italy

[17] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman & Child Hlth, I-00168 Rome, Italy

[18] Fdn Policlin Univ A Gemelli IRCCS, Publ Hlth, Publ Hlth Area, I-00168 Rome, Italy

[19] Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo 1040045, Japan

[20] Natl Inst Biomed Innovat Hlth & Nutr, Tokyo 1628636, Japan

[21] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[22] Univ West Attica, Sch Publ Hlth, Dept Publ & Community Hlth, Athens 11521, Greece

[23] Natl & Kapodistrian Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens 11527, Greece

[24] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[25] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA

[26] AC Camargo Canc Ctr, Ctr Int Pesquisa, BR-01509010 Sao Paulo, Brazil

[27] Inst Saude Publ Univ Porto, EPIUnit, P-4050600 Porto, Portugal

[28] Lab Invest Integrat & Translac Saude Populac ITR, P-4050600 Porto, Portugal

[29] Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, P-4200319 Porto, Portugal

[30] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante 46020, Spain

[31] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid 28029, Spain

[32] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA

[33] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy

[34] Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA

来源：

CANCERS | 2022年 / 14卷 / 19期

关键词：

Gastric ulcers (Gus); duodenal ulcers (DUs); risk factors; gastric cancer; HELICOBACTER-PYLORI INFECTION; AMERICAN PATIENTS; RISK; ADENOCARCINOMA; STATISTICS; JAPANESE;

D O I：

10.3390/cancers14194905

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. In this meta-analysis, we utilized SToP consortium data to investigate the association between gastric ulcer (GU) and duodenal ulcer (DU) and development of GC. Among 4106 GC cases and 6922 controls, we detected a positive association between GU and GC (OR = 3.04, 95% CI: 2.07-4.49). On the other hand, no significant association between DU and GC was detected (OR = 1.03, 95% CI: 0.77-1.39). In the pooled analysis, incorporating 11 case-control studies revealed positive association between the gastric ulcer and risk of gastric cancer. Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth's penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07-4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77-1.39). Conclusions. In the pooled analysis of 11 case-control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

引用

页数：14

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