Ester as a blocking group for palladium-catalysed direct forced arylation at the unfavourable site of heteroaromatics: simple access to the less accessible regioisomers

被引：24

作者：

Chen, Lu ^{[1
]}

Bruneau, Christian ^{[1
]}

Dixneuf, Pierre H. ^{[1
]}

Doucet, Henri ^{[1
]}

机构：

[1] Univ Rennes 1, CNRS, UMR 6226, Inst Sci Chim Rennes, F-35042 Rennes, France

来源：

GREEN CHEMISTRY | 2012年 / 14卷 / 04期

关键词：

C-H ARYLATION; DIRECT C-2 ARYLATION; INCLUDING FREE (NH)-IMIDAZOLE; REGIOSELECTIVE SYNTHESIS; ROOM-TEMPERATURE; ARYL HALIDES; DERIVATIVES; PD; THIOPHENE; AZOLES;

D O I：

10.1039/c2gc16460d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of esters as blocking groups at the C2 position on a range of 3-substituted 5-membered ring heteroaromatics such as thiophenes or furans, allows control of the regioselectivity for the palladium-catalysed direct arylation at C5-H. This arylation can be followed by easy decarboxylation. This method allows sequential catalytic C5 arylation, decarboxylation and catalytic C2 arylation reactions.

引用

页码：1111 / 1124

页数：14

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