Postnatal Involution and Counter-Involution of the Thymus

被引：30

作者：

Cowan, Jennifer E. ^{[1
]}

Takahama, Yousuke ^{[2
]}

Bhandoola, Avinash ^{[1
]}

Ohigashi, Izumi ^{[3
]}

机构：

[1] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Expt Immunol Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

[3] Univ Tokushima, Inst Adv Med Sci, Div Expt Immunol, Tokushima, Japan

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

thymus; Myc; cyclin D1; growth; involution; aging; T-CELL-RECEPTOR; MEDULLARY EPITHELIAL-CELLS; CYCLIN D1 OVEREXPRESSION; NEGATIVE SELECTION; LYMPHOHEMATOPOIETIC PROGENITORS; REGENERATIVE CAPACITY; FUNCTIONAL THYMUS; TIME-COURSE; AGE; EXPRESSION;

D O I：

10.3389/fimmu.2020.00897

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.

引用

页数：11

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