Transient increase of plasma interleukin-6 after infusion of recombinant tumor necrosis factor α in advanced cancer patients

被引：0

作者：

Zubelewicz, B ^{[1
]}

Romanowski, W ^{[1
]}

Braczkowska, B ^{[1
]}

Lissoni, P ^{[1
]}

Braczkowski, R ^{[1
]}

机构：

[1] Silesian Univ, Sch Med, Dept Internal Med 5, PL-41902 Bytom, Poland

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 1998年 / 17卷 / 04期

关键词：

advanced cancer; interleukin-6; tumor necrosis factor alpha;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor Necrosis Factor alpha administered in the therapy of advanced cancer influences certain hormones and cytokines secretion. In turn, these also modulate the biological activity of Tumor Necrosis Factor alpha. It has been shown in several studies that the cytokine Interleukin -6 (IL)-6 is produced in response to various hormones and other citokines eg. Tumor Necrosis Factor (TNF alpha). In our study we focused on the Interleukin-6 (IL-6) secretion in response to TNF alpha administration in 12 patients undergoing TNF alpha biotherapy due to advanced neoplastic disease. Plasma IL-6 was estimated prior and at various time points (2, 3, 5 a,d 12 hours) after TNF alpha intravenous infusion. IL-6 level was estimated with ELISA method. In conclusion, we suggest the stimulating influence of hrec TNF alpha administered as therapy for advanced cancer on IL-6 secretion.

引用

页码：449 / 452

页数：4

共 50 条

[31] Biliary Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography [J].

Hugo R. Rosen ;

Peter J. Winkle ;

Bradley J. Kendall ;

David L. Diehl .

Digestive Diseases and Sciences, 1997, 42 :1290-1294

[32] Tumor necrosis factor, interleukin-6, endotoxin and procalcitonin in septic shock in patients with hematological malignancy [J].

Galstyan, GM ;

Berkovsky, AL ;

Zueva, VA ;

Karyakin, AV ;

Levina, AA ;

Sergeeva, EV ;

Speranskaya, LL ;

Gorodetsky, VM .

TERAPEVTICHESKII ARKHIV, 2002, 74 (07) :56-61

[33] Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients [J].

de Jong, KP ;

van Gameren, MM ;

Bijzet, J ;

Limburg, PC ;

Sluiter, WJ ;

Slooff, MJH ;

de Vries, EGE .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2001, 36 (06) :636-640

[34] The Expression and Significance of Interleukin-9, Interleukin-6 and Tumor Necrosis Factor-alpha in Colonic Mucosa of Patients with Ulcerative Colitis [J].

Qu Dong-dong ;

Jin Shi-lu ;

Liu Bao-zhen ;

Zhang Jian ;

Xue Chun-xia .

JOURNAL OF INTERNATIONAL TRANSLATIONAL MEDICINE, 2016, 4 (03) :172-178

[35] Serum Levels of Interleukin-6 and Tumor Necrosis Factor-Alpha in Diagnosis and Prognosis of Gallbladder Cancer: A Pilot Study [J].

Sharma, Poonam ;

Krishnan, M. P. Sarath ;

Gupta, Amit ;

Gupta, Sweety ;

Saxena, Rahul ;

Mirza, Anissa Atif ;

Goyal, Bela .

JOURNAL OF LABORATORY PHYSICIANS, 2024, 16 (01) :82-88

[36] THE INFLUENCE OF MODULATING SUBSTANCES ON TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-6 LEVELS AFTER INJECTION OF MURINE TUMOR-NECROSIS-FACTOR OR LIPOPOLYSACCHARIDE IN MICE [J].

LIBERT, C ;

VANBLADEL, S ;

BROUCKAERT, P ;

FIERS, W .

JOURNAL OF IMMUNOTHERAPY, 1991, 10 (04) :227-235

[37] Tumor necrosis factor-α induces expression and release of interleukin-6 by human urothelial cells [J].

Wang, Zun-Yi ;

Bjorling, Dale E. .

INFLAMMATION RESEARCH, 2011, 60 (06) :525-532

[38] LACTOFERRIN REGULATES THE RELEASE OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-6 IN-VIVO [J].

MACHNICKI, M ;

ZIMECKI, M ;

ZAGULSKI, T .

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 1993, 74 (05) :433-439

[39] Serum leptin levels and their relationship to tumor necrosis factor-α and interleukin-6 in neonatal sepsis [J].

Koç, E ;

Üstündag, G ;

Aliefendioglu, D ;

Ergenekon, E ;

Bideci, A ;

Atalay, Y .

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2003, 16 (09) :1283-1287

[40] Effects of Coenzyme Q10 Supplementation on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-α Levels in Men [J].

Gokbel, Hakki ;

Gergerlioglu, Hasan Serdar ;

Okudan, Nilsel ;

Gul, Ibrahim ;

Buyukbas, Sadik ;

Belviranli, Muaz .

JOURNAL OF MEDICINAL FOOD, 2010, 13 (01) :216-218

← 1 2 3 4 5 →