Oxidative stress and inflammation: Implications in uremia and hemodialysis

被引：128
作者：
Libetta, Carmelo [1 ,2 ]
Sepe, Vincenzo [1 ,2 ]
Esposito, Pasquale [1 ,2 ]
Galli, Francesco [3 ]
Dal Canton, Antonio [1 ,2 ]
机构：
[1] IRCCS Policlin San Matteo, Unit Nephrol Dialysis & Transplantat, Pavia, Italy
[2] Univ Pavia, I-27100 Pavia, Italy
[3] Univ Perugia, Sect Appl Biochem & Nutr Sci, Dept Internal Med, I-06100 Perugia, Italy
来源：
CLINICAL BIOCHEMISTRY | 2011年 / 44卷 / 14-15期
关键词：
Reactive oxygen species; Reactive nitrogen species; Chronic kidney disease; Acute kidney injury; Hemodialysis; Oxidative stress; C-REACTIVE-PROTEIN; STAGE RENAL-DISEASE; INTRAVENOUS ASCORBIC-ACID; CHRONIC KIDNEY-DISEASE; TUMOR-NECROSIS-FACTOR; N-ACETYLCYSTEINE; PERITONEAL-DIALYSIS; MERCURIC-CHLORIDE; CONTRAST-MEDIA; T-CELL;
D O I：
10.1016/j.clinbiochem.2011.06.988
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Oxidative response and inflammation constitute a major defense against infections, but if not properly regulated they could also lead to a number of deleterious effects. Patients affected by different stages of acute and chronic kidney disease, particularly patients on hemodialysis, present a marked activation of oxidative and inflammatory processes. This condition exposes these patients to an elevated risk of morbidity and mortality. This Review is up to date and it analyses the newest notions about pathophysiological mechanisms of oxidative stress and inflammation in patients with renal diseases, also considering the different strategies studied to counterbalance this high risk state. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：1189 / 1198
页数：10
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