Authors' reply to the Letter to the Editor: Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer

被引：1

作者：

Koizume, Shiro ^{[1
,2
]}

Kobayashi, Satoshi ^{[3
]}

Ruf, Wolfram ^{[4
]}

Miyagi, Yohei ^{[1
,2
]}

机构：

[1] Kanagawa Canc Ctr Res Inst, Mol Pathol & Genet Div, Yokohama, Kanagawa, Japan

[2] Kanagawa Canc Ctr, Pathol Div, Yokohama, Kanagawa, Japan

[3] Kanagawa Canc Ctr, Hepatobiliary & Pancreat Med Oncol Div, Dept Gastroenterol, Yokohama, Kanagawa, Japan

[4] Johannes Gutenberg Univ Mainz, Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany

来源：

CANCER SCIENCE | 2022年 / 113卷 / 05期

关键词：

ELISA; extracellular vesicle; risk factor; thromboembolism; tissue factor; COMPLEX; VIIA;

D O I：

10.1111/cas.15324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tissue factor-procoagulant activity (TF-PCA) on cells is modified by multiple molecular mechanisms of encryption and decryption. The risk of thrombosis is higher for patients with a high tissue factor antigen level at registration as this enables patient's blood more PCA-high status before the onset of cancer-associated thromboembolism (CAT). ELISA, including the Quantikine assay with validation as performed in our study, can contribute to more precise prediction of CAT.

引用

页码：1888 / 1890

页数：3

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