Chronic Cerebrospinal Venous Insufficiency (CCSVI) and Multiple Sclerosis (MS): A Critical Review

被引:3
作者
Zecca, Chiara [1 ]
Gobbi, Claudio [1 ]
机构
[1] Osped Reg Lugano, Serv Neurol, Neuroctr Svizzera Italiana, CH-6903 Lugano, Switzerland
关键词
Chronic cerebrospinal venous insufficiency; MRI; multiple sclerosis; pathogenesis; MAGNETIC-RESONANCE VENOGRAPHY; IRON DEPOSITION; VALVE INCOMPETENCE; LESIONS; FLOW; HEMODYNAMICS; INFLAMMATION; SENSITIVITY; PATHOLOGY; DRAINAGE;
D O I
10.2174/187152711797247786
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multiple sclerosis (MS) is a chronic disease of the central nervous system with not yet completely understood pathogenesis. The so called "chronic cerebrospinal venous insufficiency (CCSVI) theory" has recently emerged, supporting the concept of a cerebrospinal venous drainage impairment as the cause of MS. Since the first publication on this topic with a claimed 100% specificity and sensitivity of the condition for MS diagnosis, CCSVI theory has generated a scientific and mass media debate with a great hope for the miracle of a new possible endovascular treatment of MS (" liberation procedure"). We critically summarize the available evidence on CCSVI discussing inconsistent and incomplete replication of the original results by different groups, methodological limitations and potential therapeutic implications. We conclude that the available data are insufficient to establish conclusively a clear relationship between MS and CCSVI and do not support the role of CCSVI as the primary cause of MS. Until credible scientific evidence replicates the original results, any proposed invasive treatments of CCSVI should be discouraged.
引用
收藏
页码:757 / 761
页数:5
相关论文
共 50 条
[41]   Risk Factors for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in a Large Cohort of Volunteers [J].
Dolic, Kresimir ;
Weinstock-Guttman, Bianca ;
Marr, Karen ;
Valnarov, Vesela ;
Carl, Ellen ;
Hagemeier, Jesper ;
Brooks, Christina ;
Kilanowski, Colleen ;
Hojnacki, David ;
Ramanathan, Murali ;
Zivadinov, Robert .
PLOS ONE, 2011, 6 (11)
[42]   Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment [J].
Brod, Staley A. ;
Kramer, Larry A. ;
Cohen, Alan M. ;
Barreto, Andrew D. ;
Bui, Thanh-Tung ;
Jemelka, James R. ;
Ton, Kelly ;
Lindsey, John W. ;
Nelson, Flavia ;
Narayana, Ponnada A. ;
Wolinsky, Jerry S. .
MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (11) :1499-1507
[43]   Magnetic Resonance Venography of chronic cerebrospinal venous insufficiency in patients with associated multiple sclerosis [J].
Hartel, Marcin ;
Kluczewska, Ewa ;
Simka, Marian ;
Ludyga, Tomasz ;
Kostecki, Jacek ;
Zaniewski, Maciej .
POLISH JOURNAL OF RADIOLOGY, 2011, 76 (01) :59-62
[44]   Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency [J].
Zakaria, Maha M. A. ;
Mikhael, Shahira Y. ;
Abu Hussein, Azza K. ;
El-Din, Rania A. Salah ;
Abd El-Malak, Hany W. ;
Hewedi, Iman H. ;
Nadim, Hany S. .
FOLIA NEUROPATHOLOGICA, 2017, 55 (01) :49-59
[45]   Chronic cerebrospinal venous insufficiency in multiple sclerosis: Weighing the findings [J].
Schelling, Franz .
SANG THROMBOSE VAISSEAUX, 2012, 24 (09) :394-404
[46]   Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis [J].
Bianca Weinstock-Guttman ;
Murali Ramanathan ;
Karen Marr ;
David Hojnacki ;
Ralph HB Benedict ;
Charity Morgan ;
Eluen Ann Yeh ;
Ellen Carl ;
Cheryl Kennedy ;
Justine Reuther ;
Christina Brooks ;
Kristin Hunt ;
Makki Elfadil ;
Michelle Andrews ;
Robert Zivadinov .
BMC Neurology, 12
[47]   Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: History and Background [J].
Dake, Michael D. .
TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY, 2012, 15 (02) :94-100
[48]   Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: Fact or Fiction!? [J].
Radak, Djordje ;
Kolar, Jovo ;
Antonic, Zelimir ;
Sagic, Dragan ;
Tanaskovic, Slobodan ;
Babic, Srdan ;
Ilijevski, Nenad .
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2011, 34 (05) :1115-1116
[49]   Chronic cerebrospinal venous insufficiency in Multiple Sclerosis: A note for caution [J].
Bhatia, Rohit ;
Abhishek ;
Prasad, Kameshwar .
ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2012, 15 (01) :2-5
[50]   Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis: Fact or Fiction!? [J].
Djordje Radak ;
Jovo Kolar ;
Želimir Antonić ;
Dragan Sagić ;
Slobodan Tanasković ;
Srđan Babić ;
Nenad Ilijevski .
CardioVascular and Interventional Radiology, 2011, 34 :1115-1116