Potentiation of Antibacterial Activity of the MB-1 Siderophore-Monobactam Conjugate Using an Efflux Pump Inhibitor

被引：27

作者：

Tomaras, Andrew P. ^{[1
]}

Crandon, Jared L. ^{[2
]}

McPherson, Craig J. ^{[1
]}

Nicolau, David P. ^{[2
]}

机构：

[1] Pfizer Inc, Worldwide Res & Dev, Antibacterials Res Unit, Groton, CT 06340 USA

[2] Hartford Hosp, Ctr Antiinfect Res & Dev, Hartford, CT 06115 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 04期

关键词：

PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; LISTERIA-MONOCYTOGENES; ESCHERICHIA-COLI; CIPROFLOXACIN; RESISTANCE; RESERPINE; TRANSPORTERS; MOXIFLOXACIN; SYSTEM;

D O I：

10.1128/AAC.04172-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Preliminary enthusiasm over the encouraging spectrum and in vitro activities of siderophore conjugates, such as MB-1, was recently tempered by unexpected variability in in vivo efficacy. The need for these conjugates to compete for iron with endogenously produced siderophores has exposed a significant liability for this novel antibacterial strategy. Here, we have exploited dependence on efflux for siderophore secretion in Pseudomonas aeruginosa and provide evidence that efflux inhibition may circumvent this in vivo-relevant resistance liability.

引用

页码：2439 / 2442

页数：4

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