Serum C-reactive protein to albumin ratio and mortality associated with peritoneal dialysis

被引:17
作者
Liu, Siyi [1 ]
Qiu, Panlin [1 ]
Luo, Laimin [1 ]
Jiang, Lei [1 ]
Chen, Yanbing [1 ]
Yan, Caixia [1 ]
Zhan, Xiaojiang [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 1, Dept Nephrol, 17 Yongwai St, Nanchang 330006, Jiangxi, Peoples R China
关键词
Serum C-reactive protein to albumin ratio; peritoneal dialysis; mortality; serum C-reactive protein; albumin; PROTEIN/ALBUMIN RATIO; PREALBUMIN LEVELS; INFLAMMATION; PREDICTOR;
D O I
10.1080/0886022X.2020.1783680
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background:Serum C-reactive protein to albumin ratio (CAR) was recently identified as a poor marker of prognosis among various populations. The current study aimed to examine the association between CAR and all-cause mortality among patients undergoing peritoneal dialysis (PD). Methods:A total of 758 patients with PD were included in this study during the period from 1 November 2005 to 28 February 2017 and followed up until 31 May 2017. The primary outcome was all-cause mortality. We used multivariate Cox proportional hazard models and Kaplan-Meier survival curves to assess the relationship between CAR and all-cause mortality in these patients. Results:Among 758 participants, mean age was 49.1 +/- 14.2 years, with 56% males and 18.6% prevalence of diabetes. Median CAR was 0.13 (interquartile range [IQR], 0.07-0.34). After 27 months (IQR, 14-40 months) of follow-up, 157 deaths had been reported. After adjusting for confounding factors, we found a significant association between serum CAR and all-cause mortality among those in the highest CAR group (hazard ratio 1.91, 95% confidence interval 1.05- 3.47,p = 0.034). Conclusions:In patients undergoing PD, an increase in serum CAR is independently associated with increased risk for all-cause mortality.
引用
收藏
页码:600 / 606
页数:7
相关论文
共 28 条
[11]   Low prealbumin levels are independently associated with higher mortality in patients on peritoneal dialysis [J].
Lee, Kyung Hee ;
Cho, Jang-Hee ;
Kwon, Owen ;
Kim, Sang-Un ;
Kim, Ryang Hi ;
Cho, Young Wook ;
Jung, Hee-Yeon ;
Choi, Ji-Young ;
Kim, Chan-Duck ;
Kim, Yong-Lim ;
Park, Sun-Hee .
KIDNEY RESEARCH AND CLINICAL PRACTICE, 2016, 35 (03) :169-175
[12]   Inflammation and Peritoneal Dialysis [J].
Li, Philip Kam-Tao ;
Ng, Jack Kit-Chung ;
Mcintyre, Christopher William .
SEMINARS IN NEPHROLOGY, 2017, 37 (01) :54-65
[13]  
Llop-Talaveron J, 2018, CLIN NUTR, V37, P1575, DOI [10.1016/j.clnu.2017.08.013, 10.101]
[14]   Nutritional predictors of mortality in prevalent peritoneal dialysis patients [J].
Malgorzewicz, Sylwia ;
Chmielewski, Michal ;
Kaczkan, Malgorzata ;
Borek, Paulina ;
Lichodziejewska-Niemierko, Monika ;
Rutkowski, Boleslaw .
ACTA BIOCHIMICA POLONICA, 2016, 63 (01) :111-115
[15]   C-reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer [J].
Mao, Minjie ;
Wei, Xiaoli ;
Sheng, Hui ;
Chi, Peidong ;
Liu, Yijun ;
Huang, Xiaoyan ;
Xiang, Yifan ;
Zhu, Qianying ;
Xing, Shan ;
Liu, Wanli .
ONCOLOGY LETTERS, 2017, 14 (06) :7417-7424
[16]   C-Reactive Protein to Serum Albumin Ratio Is an Independent Predictor of All-Cause Mortality in Patients with ANCA-Associated Vasculitis [J].
Moon, Jae-Seung ;
Ahn, Sung Soo ;
Park, Yong-Beom ;
Lee, Sang-Kyou ;
Lee, Sang-Won .
YONSEI MEDICAL JOURNAL, 2018, 59 (07) :865-871
[17]   Effect of C-reactive protein/albumin ratio on prognosis in advanced non-small-cell lung cancer [J].
Ni, Xue-Feng ;
Wu, Jun ;
Ji, Mei ;
Shao, Ying-Jie ;
Xu, Bin ;
Jiang, Jing-Ting ;
Wu, Chang-Ping .
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2018, 14 (06) :402-409
[18]  
Oh J, 2017, CLIN EXP EMERG MED, V4, P19, DOI 10.15441/ceem.16.158
[19]   Clinical usefulness of C-reactive protein to albumin ratio in predicting 30-day mortality in critically ill patients: A retrospective analysis [J].
Oh, Tak Kyu ;
Song, In-Ae ;
Lee, Jae Ho .
SCIENTIFIC REPORTS, 2018, 8
[20]   C-Reactive Protein/Albumin Ratio Predicts 90-Day Mortality of Septic Patients [J].
Ranzani, Otavio T. ;
Zampieri, Fernando Godinho ;
Forte, Daniel Neves ;
Pontes Azevedo, Luciano Cesar ;
Park, Marcelo .
PLOS ONE, 2013, 8 (03)