Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review

被引：43

作者：

Jayaram, Prathap ^{[1
]}

Ikpeama, Uzoh ^{[1
]}

Rothenberg, Joshua B. ^{[2
,3
]}

Malanga, Gerard A. ^{[4
,5
,6
]}

机构：

[1] Baylor Coll Med, H Ben Taub Dept Phys Med & Rehabil, Orthoped Surg, 1 Baylor Plaza, Houston, TX 77030 USA

[2] Boca Raton Reg Hosp, BocaCare Orthoped, Dept Regenerat Med, Boca Raton, FL USA

[3] Boca Raton Reg Hosp, BocaCare Orthoped, Dept Orthoped Biol, Boca Raton, FL USA

[4] Rutgers Sch Biomed & Hlth Sci, Dept Phys Med & Rehabil, Newark, NJ USA

[5] Rutgers State Univ, Cedar Knolls, NJ USA

[6] New Jersey Regenerat Med Inst, Cedar Knolls, NJ USA

来源：

PM&R | 2019年 / 11卷 / 02期

关键词：

INTRAARTICULAR INJECTION; RAT MODEL; CARTILAGE; TISSUE; FAT; EFFICACY;

D O I：

10.1016/j.pmrj.2018.06.019

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Regenerative medicine in the context of musculoskeletal injury is a broad term that offers potential therapeutic solutions to restore or repair damaged tissue. The current focus in recent literature and clinical practice has been on cell based therapy. In particular, much attention has been centered on autologous bone marrow concentrate and adipose-derived mesenchymal stem cells (MSCs) for cartilage and tendon disorders. This article provides an overview of MSC-derived therapy and offers a comprehensive review of adipose- and bone marrow-derived MSC therapy in primary knee osteoarthritis.

引用

页码：177 / 191

页数：15

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