Human DHHC proteins: A spotlight on the hidden player of palmitoylation

被引：115
作者：
Korycka, Justyna [1 ]
Lach, Agnieszka [1 ]
Heger, Elzbieta [2 ]
Boguslawska, Dzamila M. [2 ]
Wolny, Marcin [1 ]
Toporkiewicz, Monika [1 ]
Augoff, Katarzyna [3 ]
Korzeniewski, Jan [4 ]
Sikorski, Aleksander F. [1 ]
机构：
[1] Univ Wroclaw, Biotechnol Fac, Lab Cytobiochem, PL-51148 Wroclaw, Poland
[2] Univ Zielona Gora, Dept Mol Biol, Fac Biol Sci, PL-65565 Zielona Gora, Poland
[3] Med Univ Wroclaw, Dept Gastrointestinal & Gen Surg, Wroclaw, Poland
[4] Med Univ Wroclaw, Clin Gynecol & Obstet, PL-50367 Wroclaw, Poland
来源：
EUROPEAN JOURNAL OF CELL BIOLOGY | 2012年 / 91卷 / 02期
关键词：
Protein acyltransferases; DHHC/ZDHHC; Membrane localization; Protein palmitoylation; HUNTINGTIN-INTERACTING PROTEIN-14; CYSTEINE-RICH DOMAIN; ALLELIC LOSS; MEDIATED PALMITOYLATION; MEMBRANE INTERACTIONS; NEURONAL DEVELOPMENT; TRANSFERASE-ACTIVITY; COLORECTAL-CANCER; GABA(A) RECEPTORS; GENETIC-VARIATION;
D O I：
10.1016/j.ejcb.2011.09.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Palmitoylation is one of the most common posttranslational lipid modifications of proteins and we now know quite a lot about it. However, the state of knowledge about the enzymes that catalyze this process is clearly insufficient. This review is focused on 23 human DHHC genes and their products - protein palmitoyltransferases. Here we describe mainly the structure and function of these proteins, but also, to a lesser degree, what the substrates of the enzymes are and whether they are related to various diseases. The main aim of this review was to catalogue existing information concerning the human DHHC family of genes/proteins, making them and their functions easier to understand. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：107 / 117
页数：11
相关论文
共 103 条
[1]   Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: expression of DSC2 in gastric cancer with intestinal phenotype [J].
Anami, Katsuhiro ;
Oue, Naohide ;
Noguchi, Tsuyoshi ;
Sakamoto, Naoya ;
Sentani, Kazuhiro ;
Hayashi, Tetsutaro ;
Hinoi, Takao ;
Okajima, Masazumi ;
Graff, Jonathan M. ;
Yasui, Wataru .
JOURNAL OF PATHOLOGY, 2010, 221 (03) :275-284
[2]  
Anbazhagan R, 1998, AM J PATHOL, V152, P815
[3]   Paralemmin-1, a modulator of filopodia induction is required for spine maturation [J].
Arstikaitis, Pamela ;
Gauthier-Campbell, Catherine ;
Gutierrez Herrera, Rosario Carolina ;
Huang, Kun ;
Levinson, Joshua N. ;
Murphy, Timothy H. ;
Kilimann, Manfred W. ;
Sala, Carlo ;
Colicos, Michael A. ;
El-Husseini, Alaa .
MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (05) :2026-2038
[4]   Palmitoylation cycles and regulation of protein function (Review) [J].
Baekkeskov, Steinnunn ;
Kanaani, Jamil .
MOLECULAR MEMBRANE BIOLOGY, 2009, 26 (1-2) :42-54
[5]   Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box [J].
Baumgart, Florian ;
Corral-Escariz, Maria ;
Perez-Gil, Jesus ;
Rodriguez-Crespo, Ignacio .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2010, 1798 (03) :592-604
[6]   The on-off story of protein palmitoylation [J].
Bijlmakers, MJ ;
Marsh, M .
TRENDS IN CELL BIOLOGY, 2003, 13 (01) :32-42
[7]  
BOVA GS, 1993, CANCER RES, V53, P3869
[8]   Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8 [J].
Chen, WY ;
Shi, YY ;
Zheng, YL ;
Zhao, XZ ;
Zhang, GJ ;
Chen, SQ ;
Yang, PD ;
He, L .
HUMAN MOLECULAR GENETICS, 2004, 13 (23) :2991-2995
[9]   GABAA receptor associated proteins:: a key factor regulating GABAA receptor function [J].
Chen, Zi-Wei ;
Olsen, Richard W. .
JOURNAL OF NEUROCHEMISTRY, 2007, 100 (02) :279-294
[10]   Palmitoylation and depalmitoylation dynamics at a glance [J].
Conibear, Elizabeth ;
Davis, Nicholas G. .
JOURNAL OF CELL SCIENCE, 2010, 123 (23) :4007-4010
12345678910