Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals

被引：73

作者：

Pfeifer, Yvonne ^{[1
]}

Schlatterer, Kathrin ^{[2
]}

Engelmann, Elisabeth ^{[3
]}

Schiller, Reinhold A. ^{[4
]}

Frangenberg, Hans Reiner ^{[5
]}

Stiewe, Doris ^{[6
]}

Holfelder, Martin ^{[7
]}

Witte, Wolfgang ^{[1
]}

Nordmann, Patrice ^{[8
]}

Poirel, Laurent ^{[8
]}

机构：

[1] Robert Koch Inst, Wernigerode, Germany

[2] Univ Greifswald, Dept Clin Chem & Lab Med, Greifswald, Germany

[3] Sankt Gertrauden Hosp, Cent Lab, Berlin, Germany

[4] Charite, Inst Microbiol & Hyg, Berlin, Germany

[5] Evangel Krankenhaus, Inst Lab Med & Clin Microbiol, Oberhausen, Germany

[6] Med Lab Wahl, Ludenscheid, Germany

[7] Limbach Lab, Heidelberg, Germany

[8] Hop Bicetre, Dept Microbiol, Le Kremlin De Bicetre, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期

关键词：

BETA-LACTAMASE; ESCHERICHIA-COLI; RESISTANCE; PLASMID; SPREAD;

D O I：

10.1128/AAC.05315-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.

引用

页码：2125 / 2128

页数：4

共 19 条

[1]

[Anonymous], 2012, ANTIMICROB AGENTS CH, DOI DOI 10.1128/AAC.05289-11

[2] Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of β-lactam resistance genes [J].