Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma

被引：42
|
作者：
Kaz, Andrew M. [1 ,2 ,3 ]
Grady, William M. [2 ,3 ]
Stachler, Matthew D. [4 ]
Bass, Adam J. [5 ]
机构：
[1] VA Puget Sound Hlth Care Syst, R&D Dept, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
[3] Univ Washington, Sch Med, Dept Internal Med, Seattle, WA 98195 USA
[4] Harvard Univ, Sch Med, Dept Pathol, Brigham & Womens Hosp, Boston, MA 02115 USA
[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2015年 / 44卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Barrett's esophagus; Esophageal adenocarcinoma; Cancer genomics; LOH; Aneuploidy; Genomic instability; DNA methylation; METHYLATION INHIBITS BINDING; CPG ISLAND SHORES; DNA METHYLATION; NEOPLASTIC PROGRESSION; PROMOTER HYPERMETHYLATION; EARLY EVENT; POTENTIAL BIOMARKER; CLONAL EXPANSION; POOR-PROGNOSIS; E-CADHERIN;
D O I：
10.1016/j.gtc.2015.02.015
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), wherein normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. BE can progress to low- and high-grade dysplasia, intramucosal, and invasive carcinoma. Both BE and EAC are characterized by loss of heterozygosity, aneuploidy, specific genetic mutations, and clonal diversity. Given the limitations of histopathology, genomic and epigenomic analyses may improve the precision of risk stratification. Assays to detect molecular alterations associated with neoplastic progression could be used to improve the pathologic assessment of BE/EAC and to select high-risk patients for more intensive surveillance.
引用
收藏
页码：473 / +
页数：18
相关论文
共 50 条
  • [1] Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma
    Agarwal, Archana
    Polineni, Rahul
    Hussein, Zulfiqar
    Vigoda, Ivette
    Bhagat, Tushar D.
    Bhattacharyya, Sanchari
    Maitra, Anirban
    Verma, Amit
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2012, 5 (05): : 382 - 396
  • [2] Epigenetic Alterations from Barrett's Esophagus to Esophageal Adenocarcinoma
    Ergun, Pelin
    Kipcak, Sezgi
    Bor, Serhat
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [3] Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus
    Pinto, Rita
    Hauge, Tobias
    Jeanmougin, Marine
    Pharo, Heidi D.
    Kresse, Stine H.
    Honne, Hilde
    Winge, Sara B.
    Five, May-Britt
    Kumar, Theresa
    Mala, Tom
    Hauge, Truls
    Johnson, Egil
    Lind, Guro E.
    CLINICAL EPIGENETICS, 2022, 14 (01)
  • [4] Biomarkers in Barrett's esophagus and esophageal adenocarcinoma: Predictors of progression and prognosis
    Ong, Chin-Ann J.
    Lao-Sirieix, Pierre
    Fitzgerald, Rebecca C.
    WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (45) : 5669 - 5681
  • [5] Distinct microbiome dysbiosis and epigenetic anomaly in esophageal adenocarcinoma and its underlying Barrett's esophagus
    Shijimaya, Takuya
    Tahara, Tomomitsu
    Yamazaki, Jumpei
    Kobayashi, Sanshiro
    Matsumoto, Yasushi
    Nakamura, Naohiro
    Takahashi, Yu
    Tomiyama, Takashi
    Fukui, Toshiro
    Shibata, Tomoyuki
    Naganuma, Makoto
    CLINICAL EPIGENETICS, 2024, 16 (01)
  • [6] Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma
    Luebeck, E. Georg
    Curtius, Kit
    Hazelton, William D.
    Maden, Sean
    Yu, Ming
    Thota, Prashanthi N.
    Patil, Deepa T.
    Chak, Amitabh
    Willis, Joseph E.
    Grady, William M.
    CLINICAL EPIGENETICS, 2017, 9
  • [7] Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett’s esophagus
    Rita Pinto
    Tobias Hauge
    Marine Jeanmougin
    Heidi D. Pharo
    Stine H. Kresse
    Hilde Honne
    Sara B. Winge
    May-Britt Five
    Theresa Kumar
    Tom Mala
    Truls Hauge
    Egil Johnson
    Guro E. Lind
    Clinical Epigenetics, 2022, 14
  • [8] Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma
    E. Georg Luebeck
    Kit Curtius
    William D. Hazelton
    Sean Maden
    Ming Yu
    Prashanthi N. Thota
    Deepa T. Patil
    Amitabh Chak
    Joseph E. Willis
    William M. Grady
    Clinical Epigenetics, 2017, 9
  • [9] Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues
    Tahara, Tomomitsu
    Shijimaya, Takuya
    Yamazaki, Jumpei
    Kobayashi, Sanshiro
    Horitani, Anna
    Matsumoto, Yasushi
    Nakamura, Naohiro
    Okazaki, Takashi
    Takahashi, Yu
    Tomiyama, Takashi
    Honzawa, Yusuke
    Fukata, Norimasa
    Fukui, Toshiro
    Naganuma, Makoto
    CANCER INVESTIGATION, 2024, 42 (06) : 469 - 477
  • [10] Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma
    Fang, Yu
    Chen, Xiaoxin
    Bajpai, Manisha
    Verma, Amit
    Das, Kiron M.
    Souza, Rhonda F.
    Garman, Katherine S.
    Donohoe, Claire L.
    O'Farrell, Naoimh J.
    Reynolds, John V.
    Dvorak, Katerina
    11TH OESO WORLD CONFERENCE: REFLUX DISEASE, 2013, 1300 : 187 - 199
12345