Human pre-implantation embryo development

被引：261
作者：
Niakan, Kathy K. [2 ,3 ,4 ]
Han, Jinnuo [1 ]
Pedersen, Roger A. [3 ,4 ,5 ]
Simon, Carlos [6 ,7 ]
Pera, Renee A. Reijo [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England
[3] Univ Cambridge, Anne McLaren Lab Regenerat Med, Cambridge CB2 0SZ, England
[4] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 0SZ, England
[5] Univ Cambridge, Dept Surg, Cambridge CB2 0QQ, England
[6] Univ Valencia, Ctr Invest Principe Felipe, Valencia 46015, Spain
[7] Univ Valencia, IVI, Valencia 46015, Spain
来源：
DEVELOPMENT | 2012年 / 139卷 / 05期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
Human embryo; Oocyte to embryo transition; Zygote; Cleavage division; Blastocyst; Human embryonic stem cells; Aneuploidy; STEM-CELL LINES; COMPARATIVE GENOMIC HYBRIDIZATION; NORMAL MOUSE DEVELOPMENT; GENE-EXPRESSION; IN-VITRO; DNA METHYLATION; SELF-RENEWAL; MAINTAIN PLURIPOTENCY; SPONTANEOUS-ABORTIONS; MAMMALIAN DEVELOPMENT;
D O I：
10.1242/dev.060426
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and genomic technologies have helped to increase our understanding of this fascinating stage of human development. Here, we summarize what is currently known about human pre-implantation embryo development and highlight how further studies of human pre-implantation embryos can be used to improve ART and to fully harness the potential of hESCs for therapeutic goals.
引用
收藏
页码：829 / 841
页数：13
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