Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry

被引：6

作者：

Tong, Juliana ^{[1
,2
]}

Kavianinia, Iman ^{[1
,2
,3
]}

Ferguson, Scott A. ^{[4
]}

Cook, Gregory M. ^{[4
]}

Harris, Paul W. R. ^{[1
,2
,3
]}

Brimble, Margaret A. ^{[1
,2
,3
]}

机构：

[1] Univ Auckland, Sch Chem Sci, 23 Symonds St, Auckland 1010, New Zealand

[2] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovey, 3 Symonds St, Auckland, New Zealand

[3] Univ Auckland, Sch Biol Sci, 3A Symonds St, Auckland 1010, New Zealand

[4] Univ Otago, Sch Med Sci, Dept Microbiol & Immunol, 720 Cumberland St, Dunedin 9054, New Zealand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 23期

关键词：

Amino acids - Microorganisms;

D O I：

10.1039/d0ob00950d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report the synthesis of analogues of the antimicrobial lipopeptide, paenipeptin C ', by installing varying lipid moieties using thiol-ene CLipPA (Cysteine Lipidation on a Peptide or Amino Acid) chemistry. Biological evaluation against both Gram-negative and Gram-positive strains indicated that several analogues possessed potent broad-spectrum antimicrobial activity.

引用

页码：4381 / 4385

页数：5

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