Cross-Conjugated Cyclopentenone Prostaglandins. Recent Advances

被引：17
|
作者：
Loza, V. V. [1 ]
Gimazetdinov, A. M. [1 ]
Miftakhov, M. S. [1 ]
机构：
[1] Russian Acad Sci, Ufa Res Ctr, Ufa Inst Chem, Pr Oktyabrya 71, Ufa 450054, Bashkortostan, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 54卷 / 11期
基金：
俄罗斯基础研究基金会;
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; PAUSON-KHAND REACTION; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); DELTA(12)-PROSTAGLANDIN J(3); 2,4-DISUBSTITUTED CYCLOPENTENONES; ASYMMETRIC-SYNTHESIS; BIOLOGICAL-ACTIVITY; OXIDATIVE STRESS; PHASE SYNTHESIS; HIGHLY POTENT;
D O I：
10.1134/S1070428018110015
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The review covers the literature on the total synthesis of cross-conjugated cyclopentenone prostaglandins (PGs), published from 2000 until present. In view of the specific features differentiating cyclopentenone PGs from prostaglandins of other types, special attention in the review is focused on the biochemistry and physiological functions of the most important representatives of cyclopentenone PGs. Data on analogs of cyclopentenone PGs are presented, and certain aspects of structure-activity correlations and potential practical applications of these compounds are discussed.
引用
收藏
页码：1585 / 1629
页数：45
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