Correlative Factors of the Deterioration of Necrotizing Enterocolitis in Small for Gestational Age Newborns

被引：45
作者：
Luo, Lijuan [1 ]
Dong, Wenbin [1 ]
Zhang, Lingping [1 ]
Zhai, Xuesong [1 ]
Li, Qingping [1 ]
Lei, Xiaoping [1 ]
机构：
[1] Southwest Med Univ, Dept Newborn Med, Affiliated Hosp, Luzhou, Sichuan, Peoples R China
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
基金：
中国国家自然科学基金;
关键词：
C-REACTIVE PROTEIN;
D O I：
10.1038/s41598-017-18467-8
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Small for gestational age (SGA) infants have an increased risk of necrotizing enterocolitis (NEC), but SGA has been found to not be a risk factor for the deterioration of NEC in previous literature. Few studies have focused on correlative factors of the progression of NEC in SGA newborns. The present retrospective observational study was performed in 64 SGA infants with Bell's stage II NEC. The dependent variable was Bell's stage II NEC that progressed to stage III after diagnosis. A stepwise forward multivariate logistic regression model was used to select potential correlative factors for the progression of NEC in SGA newborns. The results showed that elevation of CRP after NEC diagnosis (aOR 39.21, 95% CI 6.62-249.2) has an increased risk for deteriorating Bell's stage II NEC. In contrast, NEC in infants with congenital heart disease had a decreased risk of deterioration (aOR 0.11, 95% CI 0.01-0.92). Our findings indicated that serial CRP measurements post NEC diagnosis may be useful in predicting the deterioration of NEC.
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页数：6
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