Effects of γ-hexachlorocyclohexane on apoptosis induced by serum deprivation in PC12 cells

被引：4

作者：

Aoki, Kentaro ^{[4
]}

Egawa, Mari ^{[4
]}

Saito, Takeshi ^{[2
]}

Hosokawa, Toshiyuki ^{[3
]}

Kurasaki, Masaaki ^{[1
,4
]}

机构：

[1] Hokkaido Univ, Fac Environm Earth Sci, Sapporo, Hokkaido 0600810, Japan

[2] Hokkaido Univ, Sch Med, Dept Hlth Sci, Sapporo, Hokkaido 0600810, Japan

[3] Hokkaido Univ, Ctr R&D Higher Educ, Sapporo, Hokkaido 0600810, Japan

[4] Hokkaido Univ, Grad Sch Environm Sci, Sapporo, Hokkaido 0600810, Japan

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES | 2008年 / 43卷 / 06期

关键词：

apoptosis; gamma-HCH; PC12; cell; caspase; cytochrome C; Bcl-2; family;

D O I：

10.1080/03601230802174573

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of -hexachlorocyclohexane, one of the endocrine disrupters, widely used for agricultural and medicinal purpose, on apoptosis in PC12 cells were investigated using western blotting analysis and reverse transcriptase-DNA polymerase chain reaction (RT-PCR) method. Apoptosis is a fundamental process necessary for development of individuals and organs. Although -HCH at high concentration did not have an effect on cell viability and apoptosis, DNA fragmentation was slightly enhanced, and apoptotic factors; Bax, Bad, cytochrome c and caspase-3 showed tendency to increase by the addition of a low dose of -HCH to the cell medium. However these changes were not statistically significant. It was concluded that -HCH did not affect on apoptosis in the PC12 cell line system, although -HCH has been reported to induce apoptosis in other cell lines.

引用

页码：471 / 475

页数：5

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