Exercise-induced modulation of monocytes in breast cancer survivors

被引：14

作者：

Khosravi, Nasim ^{[1
,2
]}

Hanson, Erik D. ^{[1
,3
]}

Farajivafa, Vahid ^{[1
,2
]}

Evans, William S. ^{[1
]}

Lee, Jordan T. ^{[1
]}

Danson, Eli ^{[1
]}

Wagoner, Chad W. ^{[1
]}

Harrell, Elizabeth P. ^{[1
]}

Sullivan, Stephanie A. ^{[1
]}

Nyrop, Kirsten A. ^{[3
,4
]}

Muss, Hyman B. ^{[3
,4
]}

Bartlett, David B. ^{[5
]}

Jensen, Brian C. ^{[6
]}

Haghighat, Shahpar ^{[7
]}

Shamsi, Mahdieh Molanouri ^{[2
]}

Battaglini, Claudio L. ^{[1
,3
,8
]}

机构：

[1] Univ N Carolina, Exercise Oncol Res Lab, Dept Exercise & Sport Sci, Chapel Hill, NC USA

[2] Tarbiat Modares Univ, Fac Humanities, Phys Educ & Sport Sci Dept, Tehran, Iran

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Hematol Oncol, Chapel Hill, NC USA

[5] Duke Univ, Dept Med, Durham, NC USA

[6] Univ N Carolina, Div Cardiol, Chapel Hill, NC USA

[7] Motamed Canc Inst, Breast Canc Res Ctr, ACECR, Tehran, Iran

[8] Univ N Carolina, 105 Fetzer Hall, CB 8700, Chapel Hill, NC 27599 USA

来源：

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH | 2021年 / 14卷

关键词：

Monocyte; Exercise; Breast cancer; Inflammation; Cytokines; Toll like receptor; IMMUNE-SYSTEM; GENE-EXPRESSION; TNF PRODUCTION; HEAT-STRESS; FATIGUE; INFLAMMATION; IMPACT; PERCENTAGE; CYTOKINES; SUBSETS;

D O I：

10.1016/j.bbih.2021.100216

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Exercise training reduces inflammation in breast cancer survivors; however, the mechanism is not fully understood. Objectives: The effects of acute and chronic exercise on monocyte toll-like receptor (TLR2 and 4) expression and intracellular cytokine production were examined in sedentary breast cancer survivors. Methods: Eleven women with stage I, II, or III breast cancer within one year of treatment completion performed an acute, intermittent aerobic exercise trial. Blood samples were obtained before, immediately, and 1 h after a 45min acute exercise trial that was performed before and after 16 weeks of combined aerobic and resistance. LPS-stimulated intracellular IL-1B, TNF, and IL-6 production, and TLR2 and TLR4 expression were evaluated in CD14+CD16- and CD14+CD16+ monocytes using flow cytometry. Results: Exercise training decreased IL-1B+CD14+CD16- proportion (24.6%, p=0.016), IL-1B+CD14+CD16- mean fluorescence intensity (MFI) (-9989, p=0.014), IL-1B+CD14+CD16+ MFI (-11101, p=0.02), and IL6+CD14+CD16- proportion (16.9%, P=0.04). TLR2 and TLR4 expression did not change following exercise training but decreased 1 h after acute exercise in CD14+CD16- (-63, p=0.002) and CD14+CD16+ (-18, p=0.006) monocytes, respectively. Immediately after the acute exercise, both monocyte subgroup cell concentration increased, with CD14+CD16+ concentrations being decreased at 1 h post without changes in intracellular cytokine production. Conclusions: Exercise training reduced monocyte intracellular pro-inflammatory cytokine production, especially IL-1B, although these markers did not change acutely. While acute exercise downregulated the expression of TLR2 and TLR4 on monocytes, this was not sustained over the course of training. These results suggest that the antiinflammatory effect of combined aerobic and resistance exercise training in breast cancer survivors may be, in part, due to reducing resting monocyte pro-inflammatory cytokine production.

引用

页数：10

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