Pd-Catalyzed C-H/N-H Arylation: One-Pot Synthesis of Indolo[1,2-f]phenanthridines

被引：8

作者：

Kong, Lingkai ^{[1
]}

Yao, Qiyi ^{[1
]}

Wang, Mengdan ^{[1
]}

Sun, Ruizhuo ^{[1
]}

Li, Yanzhong ^{[1
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dong Chuan Rd, Shanghai 200241, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

2-Bromo-2 '-iodo-1,1 '-biphenyl; C-H activation; Indolo[1,2-f]phenanthridines; palladium catalysis; BENZIMIDAZOLE-FUSED PHENANTHRIDINES; AMINATION REACTIONS; ROOM-TEMPERATURE; ANTITUMOR AGENTS; C-3; ARYLATION; ARYL BROMIDES; INDOLES; 2-ARYLBENZIMIDAZOLES; NANOPARTICLES; ACTIVATION;

D O I：

10.1002/slct.201701939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Pd-catalyzed method for the synthesis of indolo[1,2-f]phenanthridines from 2-bromo-2-iodo-1,1-biphenyl and indole derivatives has been reported. The reaction involves direct N-H and C2-H arylation of indole. This Pd-catalyzed double arylation provides a useful route to synthesize indolo[1,2-f]phenanthridine derivatives from simple and readily accessible starting materials.

引用

页码：456 / 460

页数：5

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