The role of actin bundling proteins in the assembly of filopodia in epithelial cells

被引：50
作者：
Khurana, Seema [1 ]
George, Sudeep P. [1 ]
机构：
[1] Univ Houston, Dept Biol & Biochem, Houston, TX 77030 USA
来源：
CELL ADHESION & MIGRATION | 2011年 / 5卷 / 05期
关键词：
epithelial cell; fascin; villin; actin bundling; PIP2; binding; collective cell migration; microvilli; EMT; metastases; INSULIN-RECEPTOR SUBSTRATE; DROSOPHILA DORSAL CLOSURE; MICROVILLAR CORE PROTEINS; INTESTINAL BRUSH-BORDERS; VILLIN-LIKE PROTEIN; IN-VIVO; ALPHA-ACTININ; ELEGANS HYPODERMIS; JUNCTION FORMATION; DENDRITIC NETWORK;
D O I：
10.4161/cam.5.5.17644
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The goal of this review is to highlight how emerging new models of filopodia assembly which include tissue specific actin-bundling proteins could provide more comprehensive representations of filopodia assembly that would describe more adequately and effectively the complexity and plasticity of epithelial cells. This review also describes how the true diversity of actin bundling proteins must be considered to predict the far-reaching significance and versatile functions of filopodia in epithelial cells.
引用
收藏
页码：409 / 420
页数：12
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