Role of aspirin for prevention and treatment of perioperative cardiovascular events

被引：10

作者：

Duceppe, E. ^{[1
]}

Mrkobrada, M. ^{[2
]}

Thomas, S. ^{[3
]}

Devereaux, P. J. ^{[1
,4
,5
]}

机构：

[1] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[2] Univ Western Ontario, Dept Med, Schulich Sch Med & Dent, London, ON, Canada

[3] Univ Rochester, Dept Med, Rochester, NY USA

[4] McMaster Univ, Dept Med, Hamilton, ON, Canada

[5] Populat Hlth Res Inst, Perioperat Med & Surg Res Unit, Hamilton, ON L8L 2X2, Canada

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2015年 / 13卷

关键词：

aspirin; cardiology; cardiovascular diseases; myocardial infarction; perioperative care; UNTREATED HYPERTENSIVE PATIENTS; ACUTE KIDNEY INJURY; LOW-DOSE ASPIRIN; NONCARDIAC SURGERY; MYOCARDIAL-INFARCTION; ACETYLSALICYLIC-ACID; VASCULAR-SURGERY; ISCHEMIA; TRIAL; RISK;

D O I：

10.1111/jth.12975

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Among adults undergoing non-cardiac surgery who are at risk of a myocardial infarction, a long-standing question has been whether these patients should receive aspirin throughout the perioperative period. A large (n=10010 patients) international trial (POISE-2) demonstrated that perioperative aspirin did not prevent myocardial infarction, and the result was consistent both for patients who had been taking aspirin before the trial (continuation stratum, 4382 patients) and for patients who had not been taking aspirin before the trial (initiation stratum, 5628 patients). Aspirin did, however, increase the risk of major bleeding. Therefore, the best evidence does not support the use of aspirin for the prevention of myocardial infarction in patients undergoing non-cardiac surgery. In patients who have an indication for long-term aspirin usage and have their aspirin held during the perioperative period, it is important to ensure aspirin is restarted after the high-risk period for bleeding has passed (i.e., 8-10days after surgery).

引用

页码：S297 / S303

页数：7

共 42 条

[11] Pathology of fatal perioperative myocardial infarction: Implications regarding pathophysiology and prevention [J].

Dawood, MM ;

Gutpa, DK ;

Southern, J ;

Walia, A ;

Atkinson, JB ;

Eagle, KA .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 57 (01) :37-44

[12] Effects of extended-release metoprolol succinate inpatients undergoing non-cardiac surgery (POISE trial):: a randomised controlled trial [J].

Devereaux, P. J. ;

Yang, Homer ;

Yusuf, Salim ;

Guyatt, Gordon ;

Leslie, Kate ;

Villar, Juan Carlos ;

Xavier, Denis ;

Chrolavicius, Susan ;

Greenspan, Launi ;

Pogue, Janice ;

Pais, Prem ;

Liu, Lisheng ;

Xu, Shouchun ;

Malaga, German ;

Avezum, Alvaro ;

Chan, Matthew ;

Montori, Victor M. ;

Jacka, Mike ;

Choi, Peter .

LANCET, 2008, 371 (9627) :1839-1847

[13] Aspirin in Patients Undergoing Noncardiac Surgery [J].

Devereaux, P. J. ;

Mrkobrada, M. ;

Sessler, D. I. ;

Leslie, K. ;

Alonso-Coello, P. ;

Kurz, A. ;

Villar, J. C. ;

Sigamani, A. ;

Biccard, B. M. ;

Meyhoff, C. S. ;

Parlow, J. L. ;

Guyatt, G. ;

Robinson, A. ;

Garg, A. X. ;

Rodseth, R. N. ;

Botto, F. ;

Buse, G. Lurati ;

Xavier, D. ;

Chan, M. T. V. ;

Tiboni, M. ;

Cook, D. ;

Kumar, P. A. ;

Forget, P. ;

Malaga, G. ;

Fleischmann, E. ;

Amir, M. ;

Eikelboom, J. ;

Mizera, R. ;

Torres, D. ;

Wang, C. Y. ;

VanHelder, T. ;

Paniagua, P. ;

Berwanger, O. ;

Srinathan, S. ;

Graham, M. ;

Pasin, L. ;

Le Manach, Y. ;

Gao, P. ;

Pogue, J. ;

Whitlock, R. ;

Lamy, A. ;

Kearon, C. ;

Baigent, C. ;

Chow, C. ;

Pettit, S. ;

Chrolavicius, S. ;

Yusuf, S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (16) :1494-1503

[14] Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery [J].

Devereaux, P. J. ;

Chan, Matthew T. V. ;

Alonso-Coello, Pablo ;

Walsh, Michael ;

Berwanger, Otavio ;

Villar, Juan Carlos ;

Wang, C. Y. ;

Garutti, R. Ignacio ;

Jacka, Michael J. ;

Sigamani, Alben ;

Srinathan, Sadeesh ;

Biccard, Bruce M. ;

Chow, Clara K. ;

Abraham, Valsa ;

Tiboni, Maria ;

Pettit, Shirley ;

Szczeklik, Wojciech ;

Buse, Giovanna Lurati ;

Botto, Fernando ;

Guyatt, Gordon ;

Heels-Ansdell, Diane ;

Sessler, Daniel I. ;

Thorlund, Kristian ;

Garg, Amit X. ;

Mrkobrada, Marko ;

Thomas, Sabu ;

Rodseth, Reitze N. ;

Pearse, Rupert M. ;

Thabane, Lehana ;

McQueen, Matthew J. ;

VanHelder, Tomas ;

Bhandari, Mohit ;

Bosch, Jackie ;

Kurz, Andrea ;

Polanczyk, Carisi ;

Malaga, German ;

Nagele, Peter ;

Le Manach, Yannick ;

Leuwer, Martin ;

Yusuf, Salim .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (21) :2295-2304

[15] Characteristics and Short- Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery A Cohort Study [J].

Devereaux, P. J. ;

Xavier, Denis ;

Pogue, Janice ;

Guyatt, Gordon ;

Sigamani, Alben ;

Garutti, Ignacio ;

Leslie, Kate ;

Rao-Melacini, Purnima ;

Chrolavicius, Sue ;

Yang, Homer ;

MacDonald, Colin ;

Avezum, Alvaro ;

Lanthier, Luc ;

Hu, Weijiang ;

Yusuf, Salim .

ANNALS OF INTERNAL MEDICINE, 2011, 154 (08) :523-528

[16]

Fatah K, 1996, EUR HEART J, V17, P1362

[17]

Fleisher LA, 2014, CIRCULATION, V130, P2215, DOI 10.1161/CIR.0000000000000105

[18] The Long-Term Impact of Early Cardiovascular Therapy Intensification for Postoperative Troponin Elevation After Major Vascular Surgery [J].

Foucrier, Arnaud ;

Rodseth, Reitze ;

Aissaoui, Mohamed ;

Ibanes, Cristina ;

Goarin, Jean-Pierre ;

Landais, Paul ;

Coriat, Pierre ;

Le Manach, Yannick .

ANESTHESIA AND ANALGESIA, 2014, 119 (05) :1053-1063

[19] UNINTENTIONAL HYPOTHERMIA IS ASSOCIATED WITH POSTOPERATIVE MYOCARDIAL-ISCHEMIA [J].

FRANK, SM ;

BEATTIE, C ;

CHRISTOPHERSON, R ;

NORRIS, EJ ;

PERLER, BA ;

WILLIAMS, GM ;

GOTTLIEB, SO ;

MEINERT, C ;

ROCK, P ;

PARKER, S ;

YATES, H ;

WILLIAMS, GM ;

BRESLOW, M ;

ROSENFELD, B ;

TAYLOR, D ;

BRASFIELD, B ;

BOURKE, D ;

BEZIRDJIAN, P ;

PAUL, S ;

ACHUFF, S ;

BUCHMAN, T ;

HEITMILLER, E ;

NYHAN, D ;

SITZMAN, J ;

STEVENSON, RJ .

ANESTHESIOLOGY, 1993, 78 (03) :468-476

[20] Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury A Randomized Clinical Trial [J].

Garg, Amit X. ;

Kurz, Andrea ;

Sessler, Daniel I. ;

Cuerden, Meaghan ;

Robinson, Andrea ;

Mrkobrada, Marko ;

Parikh, Chirag R. ;

Mizera, Richard ;

Jones, Philip M. ;

Tiboni, Maria ;

Font, Adria ;

Cegarra, Virginia ;

Rojas Gomez, Maria Fernanda ;

Meyhoff, Christian S. ;

VanHelder, Tomas ;

Chan, Matthew T. V. ;

Torres, David ;

Parlow, Joel ;

de Nadal Clanchet, Miriam ;

Amir, Mohammed ;

Bidgoli, Seyed Javad ;

Pasin, Laura ;

Martinsen, Kristian ;

Malaga, German ;

Myles, Paul ;

Acedillo, Rey ;

Roshanov, Pavel S. ;

Walsh, Michael ;

Dresser, George ;

Kumar, Priya ;

Fleischmann, Edith ;

Carlos Villar, Juan ;

Painter, Thomas ;

Biccard, Bruce ;

Bergese, Sergio ;

Srinathan, Sadeesh ;

Cata, Juan P. ;

Chan, Vincent ;

Mehra, Bhupendra ;

Wijeysundera, Duminda N. ;

Leslie, Kate ;

Forget, Patrice ;

Whitlock, Richard ;

Yusuf, Salim ;

Devereaux, P. J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 312 (21) :2254-2264

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