Common variants of FTO and the risk of obesity and type 2 diabetes in Indians

被引：58

作者：

Chauhan, Ganesh ^{[2
]}

Tabassum, Rubina ^{[2
]}

Mahajan, Anubha ^{[2
]}

Dwivedi, Om Prakash ^{[2
]}

Mahendran, Yuvaraj ^{[2
]}

Kaur, Ismeet ^{[2
]}

Nigam, Shubhanchi ^{[2
]}

Dubey, Himanshu ^{[2
]}

Varma, Binuja ^{[4
]}

Madhu, Sri Venkata ^{[3
]}

Mathur, Sandeep K. ^{[6
]}

Ghosh, Saurabh ^{[5
]}

Tandon, Nikhil ^{[1
]}

Bharadwaj, Dwaipayan ^{[2
]}

机构：

[1] All India Inst Med Sci, Dept Endocrinol, New Delhi 110029, India

[2] CSIR, Inst Genom & Integrat Biol, Genom & Mol Med Unit, Delhi 110007, India

[3] Univ Coll Med Sci, Div Endocrinol, Delhi 110095, India

[4] Ctr Genom Applicat, New Delhi, India

[5] Indian Stat Inst, Human Genet Unit, Kolkata, India

[6] SMS Med Coll & Hosp, Dept Endocrinol, Jaipur, Rajasthan, India

来源：

JOURNAL OF HUMAN GENETICS | 2011年 / 56卷 / 10期

关键词：

diabetes; FTO; genetic variants; Indians; obesity; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; FAT MASS; METABOLIC SYNDROME; GENETIC-VARIATION; POPULATION; IGF2BP2; TCF7L2; IMPACT; HHEX;

D O I：

10.1038/jhg.2011.87

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity. However, studies in Indian population have provided inconsistent results. Here, we examined association of eight FTO variants (rs1421085, rs8050136, rs9939609, rs9930506, rs1861867, rs9926180, rs2540769 and rs708277) with obesity and type 2 diabetes in 5364 North Indians (2474 type 2 diabetes patients and 2890 non-diabetic controls) in two stages. None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes. However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. Meta-analysis of the two study population results also revealed that rs1421085, rs8050136 and rs9939609 were significantly associated with BMI both under the random-and fixed-effect models (P (random/fixed)=0.02/0.0001, 0.004/0.0006 and 0.01/0.01, respectively). In conclusion, common variants of FTO were associated with obesity, but not with type 2 diabetes in North Indian population. Journal of Human Genetics (2011) 56, 720-726; doi:10.1038/jhg.2011.87; published online 4 August 2011

引用

页码：720 / 726

页数：7

共 33 条

[1] FTO Genetic Variation and Association With Obesity in West Africans and African Americans [J].

Adeyemo, Adebowale ;

Chen, Guanjie ;

Zhou, Jie ;

Shriner, Daniel ;

Doumatey, Ayo ;

Huang, Hanxia ;

Rotimi, Charles .

DIABETES, 2010, 59 (06) :1549-1554

[2] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[3] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population [J].

Chang, Yi-Cheng ;

Liu, Pi-Hua ;

Lee, Wei-Jei ;

Chang, Tien-Jyun ;

Jiang, Yi-Der ;

Li, Hung-Yuan ;

Kuo, Shan-Shan ;

Lee, Kuang-Chin ;

Chuang, Lee-Ming .

DIABETES, 2008, 57 (08) :2245-2252

[4] Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians [J].

Chauhan, Ganesh ;

Spurgeon, Charles J. ;

Tabassum, Rubina ;

Bhaskar, Seema ;

Kulkarni, Smita R. ;

Mahajan, Anubha ;

Chavali, Sreenivas ;

Kumar, M. V. Kranthi ;

Prakash, Swami ;

Dwivedi, Om Prakash ;

Ghosh, Saurabh ;

Yajnik, Chittaranjan S. ;

Tandon, Nikhil ;

Bharadwaj, Dwaipayan ;

Chandak, Giriraj R. .

DIABETES, 2010, 59 (08) :2068-2074

[5]

Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003, DIABETES CARE, V26, DOI DOI 10.2337/DIACARE.26.2007.S5

[6] A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].

Frayling, Timothy M. ;

Timpson, Nicholas J. ;

Weedon, Michael N. ;

Zeggini, Eleftheria ;

Freathy, Rachel M. ;

Lindgren, Cecilia M. ;

Perry, John R. B. ;

Elliott, Katherine S. ;

Lango, Hana ;

Rayner, Nigel W. ;

Shields, Beverley ;

Harries, Lorna W. ;

Barrett, Jeffrey C. ;

Ellard, Sian ;

Groves, Christopher J. ;

Knight, Bridget ;

Patch, Ann-Marie ;

Ness, Andrew R. ;

Ebrahim, Shah ;

Lawlor, Debbie A. ;

Ring, Susan M. ;

Ben-Shlomo, Yoav ;

Jarvelin, Marjo-Riitta ;

Sovio, Ulla ;

Bennett, Amanda J. ;

Melzer, David ;

Ferrucci, Luigi ;

Loos, Ruth J. F. ;

Barroso, Ines ;

Wareham, Nicholas J. ;

Karpe, Fredrik ;

Owen, Katharine R. ;

Cardon, Lon R. ;

Walker, Mark ;

Hitman, Graham A. ;

Palmer, Colin N. A. ;

Doney, Alex S. F. ;

Morris, Andrew D. ;

Smith, George Davey ;

Hattersley, Andrew T. ;

McCarthy, Mark I. .

SCIENCE, 2007, 316 (5826) :889-894

[7] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population [J].

Horikoshi, M. ;

Hara, K. ;

Ito, C. ;

Shojima, N. ;

Nagai, R. ;

Ueki, K. ;

Froguel, P. ;

Kadowaki, T. .

DIABETOLOGIA, 2007, 50 (12) :2461-2466

[8] Variations in the FTO gene are associated with severe obesity in the Japanese [J].

Hotta, Kikuko ;

Nakata, Yoshio ;

Matsuo, Tomoaki ;

Kamohara, Seika ;

Kotani, Kazuaki ;

Komatsu, Ryoya ;

Itoh, Naoto ;

Mineo, Ikuo ;

Wada, Jun ;

Masuzaki, Hiroaki ;

Yoneda, Masato ;

Nakajima, Atsushi ;

Miyazaki, Shigeru ;

Tokunaga, Katsuto ;

Kawamoto, Manabu ;

Funahashi, Tohru ;

Hamaguchi, Kazuyuki ;

Yamada, Kentaro ;

Hanafusa, Toshiaki ;

Oikawa, Shinichi ;

Yoshimatsu, Hironobu ;

Nakao, Kazuwa ;

Sakata, Toshiie ;

Matsuzawa, Yuji ;

Tanaka, Kiyoji ;

Kamatani, Naoyuki ;

Nakamura, Yusuke .

JOURNAL OF HUMAN GENETICS, 2008, 53 (06) :546-553

[9] Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study [J].

Legry, Vanessa ;

Cottel, Dominique ;

Ferrieres, Jean ;

Arveiler, Dominique ;

Andrieux, Nicolas ;

Bingham, Annie ;

Wagner, Aline ;

Ruidavets, Jean-Bernard ;

Ducimetiere, Pierre ;

Amouyel, Philippe ;

Meirhaeghe, Aline .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (07) :971-975

[10] Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population [J].

Li, Huaixing ;

Wu, Ying ;

Loos, Ruth J. F. ;

Hu, Frank B. ;

Liu, Yong ;

Wang, Jing ;

Yu, Zhijie ;

Lin, Xu .

DIABETES, 2008, 57 (01) :264-268

← 1 2 3 4 →