Important molecular genetic markers of colorectal cancer

被引：86
作者：
Kudryavtseva, Anna V. [1 ,2 ]
Lipatova, Anastasia V. [1 ]
Zaretsky, Andrew R. [3 ]
Moskalev, Alexey A. [1 ]
Fedorova, Maria S. [1 ,2 ]
Rasskazova, Anastasiya S. [1 ]
Shibukhova, Galina A. [2 ]
Snezhkina, Anastasiya V. [1 ]
Kaprin, Andrey D. [2 ]
Alekseev, Boris Y. [2 ]
Dmitriev, Alexey A. [1 ]
Krasnov, George S. [1 ,4 ]
机构：
[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia
[2] Minist Healthcare Russian Federat, Natl Med Res Radiol Ctr, Moscow, Russia
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia
[4] Russian Acad Med Sci, Orekhovich Inst Biomed Chem, Moscow, Russia
来源：
ONCOTARGET | 2016年 / 7卷 / 33期
基金：
俄罗斯科学基金会;
关键词：
colorectal cancer; molecular markers; chromosomal instability; microsatellite instability; CpG island methylator phenotype; ISLAND METHYLATOR PHENOTYPE; OXALIPLATIN-BASED CHEMOTHERAPY; MESSENGER-RNA EXPRESSION; POPULATION-BASED SERIES; APC TUMOR-SUPPRESSOR; AURORA-A EXPRESSION; NF-KAPPA-B; MICROSATELLITE-INSTABILITY; COLON-CANCER; CHROMOSOMAL INSTABILITY;
D O I：
10.18632/oncotarget.9796
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) ranks third in the incidences of cancer morbidity and mortality worldwide. CRC is rather heterogeneous with regard to molecular genetic characteristics and pathogenic pathways. A wide spectrum of biomarkers is used for molecular subtype determination, prognosis, and estimation of sensitivity to different drugs in practice. These biomarkers can include germline and somatic mutations, chromosomal aberrations, genomic abnormalities, gene expression alterations at mRNA or protein level and changes in DNA methylation status. In the present review we discuss the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.
引用
收藏
页码：53959 / 53983
页数：25
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