Cellular Effects of Progranulin in Health and Disease

被引：92

作者：

De Muynck, Louis ^{[2
,3
]}

Van Damme, Philip ^{[1
,2
,3
,4
]}

机构：

[1] Univ Hosp Leuven, Dept Neurol, B-3000 Louvain, Belgium

[2] VIB, Vesalius Res Ctr, Louvain, Belgium

[3] Katholieke Univ Leuven, Neurobiol Lab, Louvain, Belgium

[4] Katholieke Univ Leuven, Dept Neurol, Louvain, Belgium

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2011年 / 45卷 / 03期

关键词：

Progranulin; Microglia; Frontotemporal degeneration; Inflammation; Tumorigenesis; GRANULIN-EPITHELIN PRECURSOR; FRONTOTEMPORAL LOBAR DEGENERATION; PROMOTES TUMOR-GROWTH; GENE-EXPRESSION; CANCER-CELLS; GRANULIN/EPITHELIN PRECURSOR; NEURITE OUTGROWTH; HOST-DEFENSE; FACTOR PCDGF; IN-VIVO;

D O I：

10.1007/s12031-011-9553-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progranulin is a fascinating multifunctional protein, which has been implicated in cell growth, wound repair, tumorigenesis, inflammation, neurodevelopment, and more recently in neurodegeneration. The mechanism of action of this protein is still largely unknown, but the knowledge about the cellular effects on various cell types is expanding. In the current review, we will summarize what is known about the cell biology of progranulin. A better understanding of the biology of progranulin will impact diverse areas of research.

引用

页码：549 / 560

页数：12

共 109 条

[1] Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging [J].

Ahmed, Zeshan ;

Sheng, Hong ;

Xu, Ya-fei ;

Lin, Wen-Lang ;

Innes, Amy E. ;

Gass, Jennifer ;

Yu, Xin ;

Hou, Harold ;

Chiba, Shuichi ;

Yamanouchi, Keitaro ;

Leissring, Malcolm ;

Petrucelli, Leonard ;

Nishihara, Masugi ;

Hutton, Michael L. ;

McGowan, Eileen ;

Dickson, Dennis W. ;

Lewis, Jada .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (01) :311-324

[2] ACROSOME BIOGENESIS BEGINS DURING MEIOSIS - EVIDENCE FROM THE SYNTHESIS AND DISTRIBUTION OF AN ACROSOMAL GLYCOPROTEIN, ACROGRANIN, DURING GUINEA-PIG SPERMATOGENESIS [J].

ANAKWE, OO ;

GERTON, GL .

BIOLOGY OF REPRODUCTION, 1990, 42 (02) :317-328

[3] TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis [J].

Arai, Tetsuaki ;

Hasegawa, Masato ;

Akiyama, Haruhiko ;

Ikeda, Kenji ;

Nonaka, Takashi ;

Mori, Hiroshi ;

Mann, David ;

Tsuchiya, Kuniaki ;

Yoshida, Marl ;

Hashizume, Yoshio ;

Oda, Tatsuro .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 351 (03) :602-611

[4] Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing [J].

Ashcroft, GS ;

Lei, KJ ;

Jin, WW ;

Longenecker, G ;

Kulkarni, AB ;

Greenwell-Wild, T ;

Hale-Donze, H ;

McGrady, G ;

Song, XY ;

Wahl, SM .

NATURE MEDICINE, 2000, 6 (10) :1147-1153

[5] ADAMTS-7, a Direct Target of PTHrP, Adversely Regulates Endochondral Bone Growth by Associating with and Inactivating GEP Growth Factor [J].

Bai, Xiao-Hui ;

Wang, Da-Wei ;

Kong, Li ;

Zhang, Yan ;

Luan, Yi ;

Kobayashi, Tatsuya ;

Kronenberg, Henry M. ;

Yu, Xiu-Ping ;

Liu, Chuan-ju .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (15) :4201-4219

[6] Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease [J].

Baker, CA ;

Manuelidis, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (02) :675-679

[7] Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 [J].

Baker, Matt ;

Mackenzie, Ian R. ;

Pickering-Brown, Stuart M. ;

Gass, Jennifer ;

Rademakers, Rosa ;

Lindholm, Caroline ;

Snowden, Julie ;

Adamson, Jennifer ;

Sadovnick, A. Dessa ;

Rollinson, Sara ;

Cannon, Ashley ;

Dwosh, Emily ;

Neary, David ;

Melquist, Stacey ;

Richardson, Anna ;

Dickson, Dennis ;

Berger, Zdenek ;

Eriksen, Jason ;

Robinson, Todd ;

Zehr, Cynthia ;

Dickey, Chad A. ;

Crook, Richard ;

McGowan, Eileen ;

Mann, David ;

Boeve, Bradley ;

Feldman, Howard ;

Hutton, Mike .

NATURE, 2006, 442 (7105) :916-919

[8] The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system [J].

Baladrón, V ;

Ruiz-Hidalgo, MJ ;

Bonvini, E ;

Gubina, E ;

Notario, V ;

Laborda, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (02) :193-204

[9] The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection [J].

Benarafa, Charaf ;

Priebe, Gregory P. ;

Remold-O'Donnell, Eileen .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1901-1909

[10] ISOLATION AND SEQUENCE OF THE GRANULIN PRECURSOR CDNA FROM HUMAN BONE-MARROW REVEALS TANDEM CYSTEINE-RICH GRANULIN DOMAINS [J].

BHANDARI, V ;

PALFREE, RGE ;

BATEMAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1715-1719

← 1 2 3 4 5 6 7 8 9 10 →