Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process

被引：3

作者：

Amstalden, Maria-Cecilia Krahenbuehl ^{[1
,2
]}

Oliveira, Jose Diogo ^{[1
]}

Strauss, Mathias ^{[3
,4
]}

Mazali, Italo Odone ^{[4
]}

Machado, Daisy ^{[1
]}

Theisen, Thais Holtz ^{[1
]}

Lancellotti, Marcelo ^{[1
,2
]}

机构：

[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil

[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP, Brazil

[3] Natl Ctr Res Energy & Mat, Brazilian Nanotechnol Natl Lab, Campinas, SP, Brazil

[4] Univ Estadual Campinas, Inst Chem, Funct Mat Lab, Campinas, SP, Brazil

来源：

FOLIA MICROBIOLOGICA | 2019年 / 64卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

RESPIRATORY-INFECTIONS; DRUG-DELIVERY; AIR-POLLUTION; NANOPARTICLES; COMPETENCE; EXPOSURE;

D O I：

10.1007/s12223-018-0631-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360luxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 +/- 0.04) and SBA-16 (ratio 2.18 +/- 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics.

引用

页码：127 / 132

页数：6

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