Development and Validation of an HPLC Method for Mefloquine Hydrochloride Determination in Tablet Dosage Form

被引：0

作者：

Andrade Nogueira, Fernando Henrique ^{[1
]}

Lana Goulart, Leticia de Paula ^{[1
]}

Cesar, Isabela da Costa ^{[1
]}

Moreira de Campos, Ligia Maria ^{[1
]}

Pianetti, Gerson Antonio ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-31270901 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF AOAC INTERNATIONAL | 2011年 / 94卷 / 04期

关键词：

LIQUID-CHROMATOGRAPHIC METHOD; BIOLOGICALLY-ACTIVE COMPOUNDS; INITIAL EXPERIMENTS; ANTIMALARIAL; MALARIA; PLASMA; BLOOD; ASSAY;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple HPLC method for determination of mefloquine hydrochloride in tablets was developed and validated. The separation was carried out on an Xterra RP18 (250 x 4.6 mm id, 5 pm particle size) analytical column. The mobile phase was 0.05 M monobasic potassium phosphate buffer (pH 3.5) methanol (40 + 60, v/v). The flow rate and wavelength were set to 1 mL/min and 283 nm, respectively. The method was specific for mefloquine hydrochloride in the presence of hydrolytic, oxidative, and photolytic degradation products. It was also linear, precise, accurate, and robust, being suitable for routine QC analyses and stability studies. The developed HPLC method was compared to a previously described spectrophotometric method.

引用

页码：1089 / 1093

页数：5

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