Idrapril, a novel ACE inhibitor

被引：1

作者：

Latini, R

Masson, S

Luvara, G

Jeremic, G

Fiordaliso, F

机构：

[1] Dept. of Cardiovascular Research, Ist. Ric. Farmacologiche Mario Negri, Milan

[2] Dept. of Cardiovascular Research, Ist. Ric. Farmacologiche Mario Negri, 20157 Milan

来源：

CARDIOVASCULAR DRUG REVIEWS | 1996年 / 14卷 / 04期

关键词：

angiotensin-converting enzyme inhibitor; heart; idrapril; antihypertensives;

D O I：

10.1111/j.1527-3466.1996.tb00318.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Idrapril, the prototype of a new clinical class of ACE inhibitors, has a pharmacological profile similar to captopril in animals. Preliminary experimental data suggest a lower potential for inducing cough compared to captopril. In humans, it has a short elimination half-life of about 2 h, but a much longer effect on RAS and blood pressure (12 to 24 h), without affecting heart rate.

引用

页码：351 / 363

页数：13

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