Production of Recombinant Proteins in Milk of Transgenic and Non-transgenic Goats

被引：16

作者：

Moura, Raylene Ramos ^{[1
]}

Melo, Luciana Magalhaes ^{[1
]}

de Figueiredo Freitas, Vicente Jose ^{[1
]}

机构：

[1] Univ Estadual Ceara, Fac Vet, Lab Fisiol & Controle Reprod, Fortaleza, Ceara, Brazil

来源：

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2011年 / 54卷 / 05期

关键词：

transgenesis; goat; recombinant protein; milk; HUMAN GROWTH-HORMONE; COLONY-STIMULATING FACTOR; CELL NUCLEAR TRANSFER; FACTOR HG-CSF; MAMMARY-GLAND; PLASMINOGEN-ACTIVATOR; HUMAN ANTITHROMBIN; HUMAN LACTOFERRIN; HUMAN LYSOZYME; CAPRA-HIRCUS;

D O I：

10.1590/S1516-89132011000500010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Among all the transgenic mammalians produced so far, goats have represented an excellent model of transgenesis when considering the factors such as the market demand for protein, volume of milk produced per lactation and reproductive rate. Various recombinant proteins have been obtained from the transgenic and non-transgenic goats, and among these, human antithrombin, produced by the transgenic goats, was the first recombinant protein of animal origin to be released as a drug for the clinical use in humans. This review reports the aspects inherent to the production of recombinant proteins in the goats, from the production of the animal bioreactors up to the expression of these proteins in their milk.

引用

页码：927 / 938

页数：12

共 78 条

[1] HUMAN GROWTH-HORMONE (HGH) SECRETION IN MILK OF GOATS AFTER DIRECT TRANSFER OF THE HGH GENE INTO THE MAMMARY-GLAND BY USING REPLICATION-DEFECTIVE RETROVIRUS VECTORS [J].

ARCHER, JS ;

KENNAN, WS ;

GOULD, MN ;

BREMEL, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :6840-6844

[2] Production of goats by somatic cell nuclear transfer [J].

Baguisi, A ;

Behboodi, E ;

Melican, DT ;

Pollock, JS ;

Destrempes, MM ;

Cammuso, C ;

Williams, JL ;

Nims, SD ;

Porter, CA ;

Midura, P ;

Palacios, MJ ;

Ayres, SL ;

Denniston, RS ;

Hayes, ML ;

Ziomek, CA ;

Meade, HM ;

Godke, RA ;

Gavin, WG ;

Overström, EW ;

Echelard, Y .

NATURE BIOTECHNOLOGY, 1999, 17 (05) :456-461

[3] Advanced assisted reproduction technologies (ART) in goats [J].

Baldassarre, H ;

Karatzas, CN .

ANIMAL REPRODUCTION SCIENCE, 2004, 82-3 :255-266

[4] State of the art in the production of transgenic goats [J].

Baldassarre, H ;

Wang, B ;

Keefer, CL ;

Lazaris, A ;

Karatzas, CN .

REPRODUCTION FERTILITY AND DEVELOPMENT, 2004, 16 (04) :465-470

[5] Effect of GnRH injection timing in the production of pronuclear-stage zygotes used for DNA microinjection [J].

Baldassarre, H ;

Wang, B ;

Gauthier, M ;

Neveu, N ;

Lazaris, A ;

Karatzas, CN .

ZYGOTE, 2004, 12 (03) :257-261

[6]

Basu S, 2002, INT J MOL MED, V10, P3

[7] Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer [J].

Behboodi, E ;

Ayres, SL ;

Memili, E ;

O'Coin, M ;

Chen, LH ;

Reggio, BC ;

Landry, AM ;

Gavin, WG ;

Meade, HM ;

Godke, RA ;

Echelard, Y .

CLONING AND STEM CELLS, 2005, 7 (02) :107-118

[8] Biosynthesis of human-type N-glycans in heterollogous systems [J].

Betenbaugh, MJ ;

Tomiya, N ;

Narang, S ;

Hsu, JTA ;

Lee, YC .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2004, 14 (05) :601-606

[9]

Bösze Z, 2008, ADV EXP MED BIOL, V606, P357

[10] Appropriate glycosylation of recombinant proteins for human use - Implications of choice of expression system [J].

Brooks, SA .

MOLECULAR BIOTECHNOLOGY, 2004, 28 (03) :241-255

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