Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-American

被引:26
|
作者
Wan, YJY [1 ]
Poland, RE
Lin, KM
机构
[1] Univ Calif Los Angeles, Harbor Med Ctr, Dept Pathol, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, Harbor Med Ctr, Dept Psychiat, Torrance, CA 90509 USA
来源
GENETIC TESTING | 1998年 / 2卷 / 01期
关键词
D O I
10.1089/gte.1998.2.79
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The major enzymes involved in the metabolism of ethanol are alcohol dehydrogenases (ADH) and aldehyde dehydrogenase (ALDH). Some of the isozymes of ADH are expressed polymorphically, Studies investigating a causal link between ADH expression and alcoholic liver disease (ALD) have so far produced conflicting results. The cytochrome P450 2E1 (CYP2E1) represents a second enzyme that can metabolize ethanol, Although normally a minor route of metabolism, its role in chronic alcoholics may be proportionately greater than in nonalcoholics because CYP2E1 is inducible by ethanol, An Rsa I restriction fragment length polymorphism (RFLP) in the 5'-flanking region of the CYP2E1 gene has been identified. Studies have shown that the mutant allele demonstrates greater transcriptional rate, protein level, and enzyme activity when compared with the wild-type allele, The association between the Rsa I site polymorphism and ALD has been reported. In this report, we examined the genotypes of ADH2(2), ALDH2(2), and CYP2E1 in a group of healthy subjects of Mexican-American descent, The ADH2(2) and ALDH2(2) frequencies are 6% and 0%, respectively, which are similar to those which have been reported for Caucasians. In contrast, the Rsa I allele frequency of the CYP2E1 gene is 16%, which is significantly higher than in Caucasians, The high RsaI allele frequency found in Mexican-Americans suggests that it might play a role in the development of ALD in this rapidly growing minority population where ALD is common.
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页码:79 / 83
页数:5
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