Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway

被引：74
作者：
Adams, Andrew B. [1 ]
Ford, Mandy L. [1 ]
Larsen, Christian P. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Surg, Emory Transplant Ctr, 101 Woodruff Circle,5105 WMB, Atlanta, GA 30322 USA
来源：
JOURNAL OF IMMUNOLOGY | 2016年 / 197卷 / 06期
关键词：
T-CELL-ACTIVATION; PLACEBO-CONTROLLED TRIAL; COLLAGEN-INDUCED ARTHRITIS; LONG-TERM ACCEPTANCE; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; IN-VIVO; PERIPHERAL HOMEOSTASIS; RENAL-TRANSPLANTATION; PRECLINICAL EFFICACY;
D O I：
10.4049/jimmunol.1601135
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory signals. TCR signaling in the absence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy. One of the best-characterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands CD80 and CD86. The development of the fusion protein CTLA-4-Ig as an experimental and subsequent therapeutic tool is one of the major success stories in modern immunology. Abatacept and belatacept are clinically approved agents for the treatment of rheumatoid arthritis and renal transplantation, respectively. Future interventions may include selective CD28 blockade to block the costimulatory potential of CD28 while exploiting the coinhibitory effects of CTLA-4.
引用
收藏
页码：2045 / 2050
页数：6
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